TY - JOUR
T1 - CD4-targeted immune intervention
T2 - a strategy for the therapy of AIDS and autoimmune disease
AU - Auffray, Charles
AU - Piatier-Tonneau, Dominique
AU - Kroemer, Guido
N1 - Funding Information:
The authors' own work was sup ported by CNRS and, in part, by grants from Agence Nationale pour la Recherche sur le SIDA, Institut National de la Sant6 et de la Recherche M~dicale, Association pour la Recherche sur le Cancer, American Foundation for AIDS research, Rhone Poulenc Sant6, and Pasteur Vaccins to CA. GK is re cipient of a fellowship of the Spanish Ministry of Science and Education. Due to space limitations, only selected references have been indicated; a full reference list is available upon request from the authors.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - The cell-surface antigen CD4 plays a pivotal role in the class II MHC-restricted response of specific T lymphocytes, and serves as the major receptor of human immunodeficiency virus (HIV). The recent elucidation of CD4 function in physiological and pathological conditions has improved prospects for CD4-targeted immune therapy by facilitating the design of therapeutic strategies aimed at blocking CD4 function, delivering immunosuppressive signals via this receptor molecule, or selectively depleting CD4+ cells.
AB - The cell-surface antigen CD4 plays a pivotal role in the class II MHC-restricted response of specific T lymphocytes, and serves as the major receptor of human immunodeficiency virus (HIV). The recent elucidation of CD4 function in physiological and pathological conditions has improved prospects for CD4-targeted immune therapy by facilitating the design of therapeutic strategies aimed at blocking CD4 function, delivering immunosuppressive signals via this receptor molecule, or selectively depleting CD4+ cells.
UR - http://www.scopus.com/inward/record.url?scp=0025978869&partnerID=8YFLogxK
U2 - 10.1016/0167-7799(91)90043-H
DO - 10.1016/0167-7799(91)90043-H
M3 - Article
C2 - 1367392
AN - SCOPUS:0025978869
SN - 0167-7799
VL - 9
SP - 124
EP - 131
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 1
ER -