CD4+ T Cells at the Center of Inflammaging

Guido Kroemer; Laurence Zitvogel

doi:10.1016/j.cmet.2020.04.016

CD4⁺ T Cells at the Center of Inflammaging

Guido Kroemer, Laurence Zitvogel

Résultats de recherche: Contribution à un journal › !!Comment/debate

18 Citations (Scopus)

Résumé

Bharath et al., 2020 report that CD4⁺ T lymphocytes from aged individuals exhibit defective mitochondrial autophagy, resulting in altered redox metabolism and upregulation of TH17 cytokines, which in turn may contribute to aging-associated chronic inflammation or “inflammaging.” Of note, the antiaging drug metformin reverses this autophagy defect and rejuvenates CD4⁺ T cell function.

langue originale	Anglais
Pages (de - à)	4-5
Nombre de pages	2
journal	Cell Metabolism
Volume	32
Numéro de publication	1
Les DOIs	https://doi.org/10.1016/j.cmet.2020.04.016
état	Publié - 7 juil. 2020

Accès au document

10.1016/j.cmet.2020.04.016

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title = "CD4+ T Cells at the Center of Inflammaging",

abstract = "Bharath et al., 2020 report that CD4+ T lymphocytes from aged individuals exhibit defective mitochondrial autophagy, resulting in altered redox metabolism and upregulation of TH17 cytokines, which in turn may contribute to aging-associated chronic inflammation or “inflammaging.” Of note, the antiaging drug metformin reverses this autophagy defect and rejuvenates CD4+ T cell function.",

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