Challenges and limits of therapeutic de-escalation for papillomavirus-related oropharyngeal cancer

A. Modesto; P. Graff Cailleaud; P. Blanchard; P. Boisselier; Y. Pointreau

doi:10.1016/j.canrad.2022.06.018

Challenges and limits of therapeutic de-escalation for papillomavirus-related oropharyngeal cancer

Titre traduit de la contribution: Enjeux et limites de la désescalade thérapeutique dans la prise en charge du cancer de l'oropharynx lié au papillomavirus

A. Modesto, P. Graff Cailleaud, P. Blanchard, P. Boisselier, Y. Pointreau

Résultats de recherche: Contribution à un journal › Article 'review' › Revue par des pairs

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Résumé

The incidence of HPV-related oropharyngeal cancers has been increasing in Western countries for several decades. If they are individualized within the latest TNM classification, the current standards of management do not authorize the management of these patients to be singled out. However, their distinct oncogenesis and their excellent prognosis compared to other patients has allowed the development of several clinical trials based on the question of therapeutic de-escalation. This review of the literature aims to take stock of the elements provided by clinical research in recent years.

Titre traduit de la contribution	Enjeux et limites de la désescalade thérapeutique dans la prise en charge du cancer de l'oropharynx lié au papillomavirus
langue originale	Anglais
Pages (de - à)	921-924
Nombre de pages	4
journal	Cancer/Radiotherapie
Volume	26
Numéro de publication	6-7
Les DOIs	https://doi.org/10.1016/j.canrad.2022.06.018
état	Publié - 1 oct. 2022

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10.1016/j.canrad.2022.06.018

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title = "Challenges and limits of therapeutic de-escalation for papillomavirus-related oropharyngeal cancer",

abstract = "The incidence of HPV-related oropharyngeal cancers has been increasing in Western countries for several decades. If they are individualized within the latest TNM classification, the current standards of management do not authorize the management of these patients to be singled out. However, their distinct oncogenesis and their excellent prognosis compared to other patients has allowed the development of several clinical trials based on the question of therapeutic de-escalation. This review of the literature aims to take stock of the elements provided by clinical research in recent years.",

keywords = "Human papillomavirus, Immunotherapy, Oropharyngeal cancer, Radiotherapy, Therapeutic de-escalation",

author = "A. Modesto and {Graff Cailleaud}, P. and P. Blanchard and P. Boisselier and Y. Pointreau",

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AU - Modesto, A.

AU - Graff Cailleaud, P.

AU - Blanchard, P.

AU - Boisselier, P.

AU - Pointreau, Y.

PY - 2022/10/1

Y1 - 2022/10/1

N2 - The incidence of HPV-related oropharyngeal cancers has been increasing in Western countries for several decades. If they are individualized within the latest TNM classification, the current standards of management do not authorize the management of these patients to be singled out. However, their distinct oncogenesis and their excellent prognosis compared to other patients has allowed the development of several clinical trials based on the question of therapeutic de-escalation. This review of the literature aims to take stock of the elements provided by clinical research in recent years.

AB - The incidence of HPV-related oropharyngeal cancers has been increasing in Western countries for several decades. If they are individualized within the latest TNM classification, the current standards of management do not authorize the management of these patients to be singled out. However, their distinct oncogenesis and their excellent prognosis compared to other patients has allowed the development of several clinical trials based on the question of therapeutic de-escalation. This review of the literature aims to take stock of the elements provided by clinical research in recent years.

KW - Human papillomavirus

KW - Immunotherapy

KW - Oropharyngeal cancer

KW - Radiotherapy

KW - Therapeutic de-escalation

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DO - 10.1016/j.canrad.2022.06.018

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