Characterization of a new p53-mutated and HPV-negative human squamous cell cervical carcinoma-derived cell line

S. Fogel, J. C. Ahomadegbe, M. L. Le Bihan, M. Barrois, G. Riou

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    2 Citations (Scopus)

    Résumé

    A new cell line, designated IGR/Cut40, has been established from a stage II squamous cell carcinoma of the uterine cervix. These cells, which have a tetraploid DNA content and typical epithelial features, displayed a high proliferation rate and a powerful tumorigenic potential in immunodeficient mice. No human papillomavirus (HPV) DNA was detected using PCR and consensus primers. Sequencing of p53 cDNA revealed a mutation CGC(Arg) → CAC(His) at codon 175 of the gene encoding for an abundant nuclear protein. ICR/Cut40 cell line should permit a better understanding of the HPV-infection-unrelated tumorigenesis of the uterine cervix.

    langue originaleAnglais
    Pages (de - à)681-686
    Nombre de pages6
    journalInternational Journal of Oncology
    Volume6
    Numéro de publication3
    Les DOIs
    étatPublié - 1 janv. 1995

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