Résumé
A new cell line, designated IGR/Cut40, has been established from a stage II squamous cell carcinoma of the uterine cervix. These cells, which have a tetraploid DNA content and typical epithelial features, displayed a high proliferation rate and a powerful tumorigenic potential in immunodeficient mice. No human papillomavirus (HPV) DNA was detected using PCR and consensus primers. Sequencing of p53 cDNA revealed a mutation CGC(Arg) → CAC(His) at codon 175 of the gene encoding for an abundant nuclear protein. ICR/Cut40 cell line should permit a better understanding of the HPV-infection-unrelated tumorigenesis of the uterine cervix.
langue originale | Anglais |
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Pages (de - à) | 681-686 |
Nombre de pages | 6 |
journal | International Journal of Oncology |
Volume | 6 |
Numéro de publication | 3 |
Les DOIs | |
état | Publié - 1 janv. 1995 |