Characterization of a novel ETS gene, TELB, encoding a protein structurally and functionaly related to TEL

Hèléne Poirel; Rodolphe G. Lopez; Virginie Lacronique; Véronique Della Valle; Martine Mauchauffé; Roland Berger; Jacques Ghysdael; Olivier A. Bernard

doi:10.1038/sj.onc.1203830

Characterization of a novel ETS gene, TELB, encoding a protein structurally and functionaly related to TEL

Hèléne Poirel, Rodolphe G. Lopez, Virginie Lacronique, Véronique Della Valle, Martine Mauchauffé, Roland Berger, Jacques Ghysdael, Olivier A. Bernard

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

30 Citations (Scopus)

Résumé

The TEL/ETV6 gene is located at 12p13 and is frequently involved in chromosomal translocations in human malignancies usually resulting in the expression of fusion proteins between the amino terminal part of TEL, and either unrelated transcription factors or protein tyrosine kinases. We report here a novel gene named TELB which is located on human chromosomal band 6p21 and encodes a protein highly related to TEL. TELB is widely expressed in different tissues and, similarly to TEL encodes a sequence-specific transcriptional repressor.

langue originale	Anglais
Pages (de - à)	4802-4806
Nombre de pages	5
journal	Oncogene
Volume	19
Numéro de publication	41
Les DOIs	https://doi.org/10.1038/sj.onc.1203830
état	Publié - 28 sept. 2000
Modification externe	Oui

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10.1038/sj.onc.1203830

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@article{f6513ed4ecf3414394b2af4147ac300e,

title = "Characterization of a novel ETS gene, TELB, encoding a protein structurally and functionaly related to TEL",

abstract = "The TEL/ETV6 gene is located at 12p13 and is frequently involved in chromosomal translocations in human malignancies usually resulting in the expression of fusion proteins between the amino terminal part of TEL, and either unrelated transcription factors or protein tyrosine kinases. We report here a novel gene named TELB which is located on human chromosomal band 6p21 and encodes a protein highly related to TEL. TELB is widely expressed in different tissues and, similarly to TEL encodes a sequence-specific transcriptional repressor.",

keywords = "ETS, TEL, Transcriptional repression",

author = "H{\`e}l{\'e}ne Poirel and Lopez, {Rodolphe G.} and Virginie Lacronique and Valle, {V{\'e}ronique Della} and Martine Mauchauff{\'e} and Roland Berger and Jacques Ghysdael and Bernard, {Olivier A.}",

note = "Funding Information: This work was supported by grants from the Association de Recherche sur le Cancer (ARC) and the Ligue Nationale Contre le Cancer (LNCC).",

year = "2000",

month = sep,

day = "28",

doi = "10.1038/sj.onc.1203830",

language = "English",

volume = "19",

pages = "4802--4806",

journal = "Oncogene",

issn = "0950-9232",

number = "41",

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TY - JOUR

T1 - Characterization of a novel ETS gene, TELB, encoding a protein structurally and functionaly related to TEL

AU - Poirel, Hèléne

AU - Lopez, Rodolphe G.

AU - Lacronique, Virginie

AU - Valle, Véronique Della

AU - Mauchauffé, Martine

AU - Berger, Roland

AU - Ghysdael, Jacques

AU - Bernard, Olivier A.

N1 - Funding Information: This work was supported by grants from the Association de Recherche sur le Cancer (ARC) and the Ligue Nationale Contre le Cancer (LNCC).

PY - 2000/9/28

Y1 - 2000/9/28

N2 - The TEL/ETV6 gene is located at 12p13 and is frequently involved in chromosomal translocations in human malignancies usually resulting in the expression of fusion proteins between the amino terminal part of TEL, and either unrelated transcription factors or protein tyrosine kinases. We report here a novel gene named TELB which is located on human chromosomal band 6p21 and encodes a protein highly related to TEL. TELB is widely expressed in different tissues and, similarly to TEL encodes a sequence-specific transcriptional repressor.

AB - The TEL/ETV6 gene is located at 12p13 and is frequently involved in chromosomal translocations in human malignancies usually resulting in the expression of fusion proteins between the amino terminal part of TEL, and either unrelated transcription factors or protein tyrosine kinases. We report here a novel gene named TELB which is located on human chromosomal band 6p21 and encodes a protein highly related to TEL. TELB is widely expressed in different tissues and, similarly to TEL encodes a sequence-specific transcriptional repressor.

KW - ETS

KW - TEL

KW - Transcriptional repression

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U2 - 10.1038/sj.onc.1203830

DO - 10.1038/sj.onc.1203830

M3 - Article

C2 - 11032031

AN - SCOPUS:0034726957

SN - 0950-9232

VL - 19

SP - 4802

EP - 4806

JO - Oncogene

JF - Oncogene

IS - 41

ER -