TY - JOUR
T1 - CHCHD4 links AIF to the biogenesis of respiratory chain complex I
AU - Modjtahedi, Nazanine
AU - Kroemer, Guido
N1 - Publisher Copyright:
© 2016, © 2016 Taylor & Francis Group, LLC.
PY - 2016/3/3
Y1 - 2016/3/3
N2 - During the evolution from yeast to mammals the Mia40 protein, the regulator of the redox-sensitive mitochondrial intermembrane space import machinery, has lost its membrane-anchorage segment to become CHCHD4, which interacts with the flavoprotein apoptosis-inducing factor (AIF). Our results establish CHCHD4 as the missing link between AIF deficiency and dysfunctional biogenesis of respiratory chain complexes.
AB - During the evolution from yeast to mammals the Mia40 protein, the regulator of the redox-sensitive mitochondrial intermembrane space import machinery, has lost its membrane-anchorage segment to become CHCHD4, which interacts with the flavoprotein apoptosis-inducing factor (AIF). Our results establish CHCHD4 as the missing link between AIF deficiency and dysfunctional biogenesis of respiratory chain complexes.
KW - Disulfide relay
KW - mitochondrial import
KW - mitochondriopathy
KW - respiratory chain complexes
UR - http://www.scopus.com/inward/record.url?scp=85030171561&partnerID=8YFLogxK
U2 - 10.1080/23723556.2015.1074332
DO - 10.1080/23723556.2015.1074332
M3 - Article
AN - SCOPUS:85030171561
SN - 2372-3556
VL - 3
JO - Molecular and Cellular Oncology
JF - Molecular and Cellular Oncology
IS - 2
M1 - e1074332
ER -