CHCHD4 links AIF to the biogenesis of respiratory chain complex I

Nazanine Modjtahedi, Guido Kroemer

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    11 Citations (Scopus)

    Résumé

    During the evolution from yeast to mammals the Mia40 protein, the regulator of the redox-sensitive mitochondrial intermembrane space import machinery, has lost its membrane-anchorage segment to become CHCHD4, which interacts with the flavoprotein apoptosis-inducing factor (AIF). Our results establish CHCHD4 as the missing link between AIF deficiency and dysfunctional biogenesis of respiratory chain complexes.

    langue originaleAnglais
    Numéro d'articlee1074332
    journalMolecular and Cellular Oncology
    Volume3
    Numéro de publication2
    Les DOIs
    étatPublié - 3 mars 2016

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