CheckMate 141: 1-Year Update and Subgroup Analysis of Nivolumab as First-Line Therapy in Patients with Recurrent/Metastatic Head and Neck Cancer

Maura L. Gillison; George Blumenschein; Jerome Fayette; Joel Guigay; A. Dimitrios Colevas; Lisa Licitra; Kevin J. Harrington; Stefan Kasper; Everett E. Vokes; Caroline Even; Francis Worden; Nabil F. Saba; Lara Carmen Iglesias Docampo; Robert Haddad; Tamara Rordorf; Naomi Kiyota; Makoto Tahara; Manish Monga; Mark Lynch; Li Li; Robert L. Ferris

doi:10.1634/theoncologist.2017-0674

CheckMate 141: 1-Year Update and Subgroup Analysis of Nivolumab as First-Line Therapy in Patients with Recurrent/Metastatic Head and Neck Cancer

Maura L. Gillison, George Blumenschein, Jerome Fayette, Joel Guigay, A. Dimitrios Colevas, Lisa Licitra, Kevin J. Harrington, Stefan Kasper, Everett E. Vokes, Caroline Even, Francis Worden, Nabil F. Saba, Lara Carmen Iglesias Docampo, Robert Haddad, Tamara Rordorf, Naomi Kiyota, Makoto Tahara, Manish Monga, Mark Lynch, Li LiRobert L. Ferris

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

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Résumé

Nivolumab significantly improved overall survival (OS) vs investigator's choice (IC) of chemotherapy at the primary analysis of randomized, open-label, phase 3 CheckMate 141 in patients with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN). Here, we report that OS benefit with nivolumab was maintained at a minimum follow-up of 11.4 months. Further, OS benefit with nivolumab vs IC was also noted among patients who received first-line treatment for R/M SCCHN after progressing on platinum therapy for locally advanced disease in the adjuvant or primary (i.e., with radiation) setting.

langue originale	Anglais
Pages (de - à)	1079-1082
Nombre de pages	4
journal	Oncologist
Volume	23
Numéro de publication	9
Les DOIs	https://doi.org/10.1634/theoncologist.2017-0674
état	Publié - 1 sept. 2018

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10.1634/theoncologist.2017-0674

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Gillison, M. L., Blumenschein, G., Fayette, J., Guigay, J., Colevas, A. D., Licitra, L., Harrington, K. J., Kasper, S., Vokes, E. E., Even, C., Worden, F., Saba, N. F., Iglesias Docampo, L. C., Haddad, R., Rordorf, T., Kiyota, N., Tahara, M., Monga, M., Lynch, M., ... Ferris, R. L. (2018). CheckMate 141: 1-Year Update and Subgroup Analysis of Nivolumab as First-Line Therapy in Patients with Recurrent/Metastatic Head and Neck Cancer. Oncologist, 23(9), 1079-1082. https://doi.org/10.1634/theoncologist.2017-0674

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title = "CheckMate 141: 1-Year Update and Subgroup Analysis of Nivolumab as First-Line Therapy in Patients with Recurrent/Metastatic Head and Neck Cancer",

abstract = "Nivolumab significantly improved overall survival (OS) vs investigator's choice (IC) of chemotherapy at the primary analysis of randomized, open-label, phase 3 CheckMate 141 in patients with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN). Here, we report that OS benefit with nivolumab was maintained at a minimum follow-up of 11.4 months. Further, OS benefit with nivolumab vs IC was also noted among patients who received first-line treatment for R/M SCCHN after progressing on platinum therapy for locally advanced disease in the adjuvant or primary (i.e., with radiation) setting.",

author = "Gillison, {Maura L.} and George Blumenschein and Jerome Fayette and Joel Guigay and Colevas, {A. Dimitrios} and Lisa Licitra and Harrington, {Kevin J.} and Stefan Kasper and Vokes, {Everett E.} and Caroline Even and Francis Worden and Saba, {Nabil F.} and {Iglesias Docampo}, {Lara Carmen} and Robert Haddad and Tamara Rordorf and Naomi Kiyota and Makoto Tahara and Manish Monga and Mark Lynch and Li Li and Ferris, {Robert L.}",

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doi = "10.1634/theoncologist.2017-0674",

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Gillison, ML, Blumenschein, G, Fayette, J, Guigay, J, Colevas, AD, Licitra, L, Harrington, KJ, Kasper, S, Vokes, EE, Even, C, Worden, F, Saba, NF, Iglesias Docampo, LC, Haddad, R, Rordorf, T, Kiyota, N, Tahara, M, Monga, M, Lynch, M, Li, L & Ferris, RL 2018, 'CheckMate 141: 1-Year Update and Subgroup Analysis of Nivolumab as First-Line Therapy in Patients with Recurrent/Metastatic Head and Neck Cancer', Oncologist, VOL. 23, Numéro 9, p. 1079-1082. https://doi.org/10.1634/theoncologist.2017-0674

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AU - Blumenschein, George

AU - Fayette, Jerome

AU - Guigay, Joel

AU - Colevas, A. Dimitrios

AU - Licitra, Lisa

AU - Harrington, Kevin J.

AU - Kasper, Stefan

AU - Vokes, Everett E.

AU - Even, Caroline

AU - Worden, Francis

AU - Saba, Nabil F.

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AU - Haddad, Robert

AU - Rordorf, Tamara

AU - Kiyota, Naomi

AU - Tahara, Makoto

AU - Monga, Manish

AU - Lynch, Mark

AU - Li, Li

AU - Ferris, Robert L.

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