Chemotherapy

Mihaela Aldea, Elena Diana Olteanu

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Résumé

Chemotherapy in pineal tumors can be used as an adjuvant treatment, in addition to radiotherapy, in selected cases of high-volume disease in the preoperative setting, or in case of tumor relapse. Tumor response greatly varies depending on histology, with higher tumor responses in case of germ cell tumors compared to those of pineal parenchyma. Germinomas are efficiently treated with chemotherapy and radiotherapy, whereas nongerminomatous germ cell tumors usually require surgical resection, chemotherapy, and radiotherapy. The most commonly used chemotherapy regimens are: combinations of platinum agents with etoposide and ifosfamide in germ cell tumors, temozolomide, platinum and etoposide or vincristine combinations in pineal cell tumors, and temozolomide in glial cell tumors. The association between radiotherapy and chemotherapy is the most frequently used strategy as a complement to surgery; however, standard treatment regimens still need to be defined.

langue originaleAnglais
titrePineal Region Lesions
Sous-titreManagement Strategies and Controversial Issues
EditeurSpringer International Publishing
Pages131-134
Nombre de pages4
ISBN (Electronique)9783030509132
ISBN (imprimé)9783030509125
Les DOIs
étatPublié - 4 nov. 2020
Modification externeOui

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