Résumé
Chemotherapy in pineal tumors can be used as an adjuvant treatment, in addition to radiotherapy, in selected cases of high-volume disease in the preoperative setting, or in case of tumor relapse. Tumor response greatly varies depending on histology, with higher tumor responses in case of germ cell tumors compared to those of pineal parenchyma. Germinomas are efficiently treated with chemotherapy and radiotherapy, whereas nongerminomatous germ cell tumors usually require surgical resection, chemotherapy, and radiotherapy. The most commonly used chemotherapy regimens are: combinations of platinum agents with etoposide and ifosfamide in germ cell tumors, temozolomide, platinum and etoposide or vincristine combinations in pineal cell tumors, and temozolomide in glial cell tumors. The association between radiotherapy and chemotherapy is the most frequently used strategy as a complement to surgery; however, standard treatment regimens still need to be defined.
langue originale | Anglais |
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titre | Pineal Region Lesions |
Sous-titre | Management Strategies and Controversial Issues |
Editeur | Springer International Publishing |
Pages | 131-134 |
Nombre de pages | 4 |
ISBN (Electronique) | 9783030509132 |
ISBN (imprimé) | 9783030509125 |
Les DOIs | |
état | Publié - 4 nov. 2020 |
Modification externe | Oui |