TY - JOUR
T1 - Chicken-Activated-T-Lymphocyte-Antigen (CATLA) recognized by monoclonal antibody INN-CH 16 represents the IL-2 receptor
AU - Schauenstein, Konrad
AU - Krömer, Guido
AU - Hála, Karel
AU - Böck, Günther
AU - Wick, Georg
N1 - Funding Information:
This paper is dedicated to Prof. W. Thiel, head of the Institute of Anatomy, University of Graz, Austria, on the occasion of his 70 th birthday. This work was supported by the Austrian Research Fund (project No. $4105), by the Jubil~iumsfonds der 0sterreichischen Nationalbank (project No 2784) and by the Austrian Cancer Research Fund. The expert technical assistance of Ms. K. Rossi is gratefully acknowledged.
PY - 1988/1/1
Y1 - 1988/1/1
N2 - Monoclonal antibody INN-CH 16 recognizes a surface determinant exclusively present on activated chicken T lymphocytes. The present experiments suggest that this chicken activated T lymphocyte antigen (CATLA) represents the chicken IL-2 receptor or an associated structure, as (i) the kinetics of CATLA expression during T cell activation are analogous to those described for the mammalian receptor for IL-2, (ii) the IL-2 dependent proliferation of mitogen prestimulated chicken lymphocytes is competitively inhibited by INN-CH 16, and (iii) pretreatment of T lymphoblasts with INN-CH 16 drastically reduces their capacity to absorb IL-2 activity from supernatants of mitogen activated chicken lymphocytes.
AB - Monoclonal antibody INN-CH 16 recognizes a surface determinant exclusively present on activated chicken T lymphocytes. The present experiments suggest that this chicken activated T lymphocyte antigen (CATLA) represents the chicken IL-2 receptor or an associated structure, as (i) the kinetics of CATLA expression during T cell activation are analogous to those described for the mammalian receptor for IL-2, (ii) the IL-2 dependent proliferation of mitogen prestimulated chicken lymphocytes is competitively inhibited by INN-CH 16, and (iii) pretreatment of T lymphoblasts with INN-CH 16 drastically reduces their capacity to absorb IL-2 activity from supernatants of mitogen activated chicken lymphocytes.
UR - http://www.scopus.com/inward/record.url?scp=0024239501&partnerID=8YFLogxK
U2 - 10.1016/0145-305X(88)90056-0
DO - 10.1016/0145-305X(88)90056-0
M3 - Article
C2 - 2850227
AN - SCOPUS:0024239501
SN - 0145-305X
VL - 12
SP - 823
EP - 831
JO - Developmental and Comparative Immunology
JF - Developmental and Comparative Immunology
IS - 4
ER -