Chimiothérapie intensive et autogreffe de cellules souches hématopoïétiques dans les tumeurs germinales

Christophe Massard, Aude Fléchon, Karim Fizazi, Jean Pierre Droz

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    Résumé

    Germ cell tumors are cured by cisplatin-based chemotherapy and secondary surgery. Patients with initial poor response to chemotherapy and relapsed disease patients have poor prognosis. Among different therapeutic approaches high dose chemotherapy with hematopoietic stem cell support has been studied. Despite the existence of a number of phase II trials and several wellconducted phase III trials, this approach is neither a standard nor an option in the setting of first line and first salvage treatment. A randomized phase III trial has recently been initiated and patients with relapsed disease should be offered to participate in the trial. Several selected indications could be discussed in further lines of treatment.

    Titre traduit de la contributionHigh dose chemotherapy and germ cell tumor
    langue originaleFrançais
    Pages (de - à)945-949
    Nombre de pages5
    journalBulletin du Cancer
    Volume98
    Numéro de publication8
    Les DOIs
    étatPublié - 1 janv. 2011

    mots-clés

    • First line treatment
    • Germ cell tumor
    • High dose chemotherapy
    • Prognostic factors
    • Randomized trials
    • Salvage treatment

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