Cholestasis in children with portal vein obstruction

Marion Gauthier-Villars; Stéphanie Franchi; Frédéric Gauthier; Monique Fabre; Danièle Pariente; Olivier Bernard

doi:10.1016/j.jpeds.2004.12.025

Cholestasis in children with portal vein obstruction

Marion Gauthier-Villars, Stéphanie Franchi, Frédéric Gauthier, Monique Fabre, Danièle Pariente, Olivier Bernard

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

36 Citations (Scopus)

Résumé

We describe cholestasis as a result of bile duct abnormalities in 8 children with portal vein obstruction. In a clinical, biochemical and radiological investigation of 121 children with cavernous transformation of the portal vein seen between 1986 and 2000, 8 presented with jaundice, pruritus, and/or raised serum aminotransferases and/or gamma glutamyl transpeptidase (gamma GT) activities. Each displayed dilation and narrowing of intra- and/or extrahepatic bile ducts. Surgical decompression of the portal system (portal-systemic or Rex anastomosis) resulted in the regression of the signs of cholestasis in all children. We conclude that children with portal vein obstruction may exhibit clinically significant cholestasis as a result of external compression of the bile duct by the cavernoma.

langue originale	Anglais
Pages (de - à)	568-573
Nombre de pages	6
journal	Journal of Pediatrics
Volume	146
Numéro de publication	4
Les DOIs	https://doi.org/10.1016/j.jpeds.2004.12.025
état	Publié - 1 janv. 2005
Modification externe	Oui

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10.1016/j.jpeds.2004.12.025

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title = "Cholestasis in children with portal vein obstruction",

abstract = "We describe cholestasis as a result of bile duct abnormalities in 8 children with portal vein obstruction. In a clinical, biochemical and radiological investigation of 121 children with cavernous transformation of the portal vein seen between 1986 and 2000, 8 presented with jaundice, pruritus, and/or raised serum aminotransferases and/or gamma glutamyl transpeptidase (gamma GT) activities. Each displayed dilation and narrowing of intra- and/or extrahepatic bile ducts. Surgical decompression of the portal system (portal-systemic or Rex anastomosis) resulted in the regression of the signs of cholestasis in all children. We conclude that children with portal vein obstruction may exhibit clinically significant cholestasis as a result of external compression of the bile duct by the cavernoma.",

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AU - Gauthier-Villars, Marion

AU - Franchi, Stéphanie

AU - Gauthier, Frédéric

AU - Fabre, Monique

AU - Pariente, Danièle

AU - Bernard, Olivier

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AB - We describe cholestasis as a result of bile duct abnormalities in 8 children with portal vein obstruction. In a clinical, biochemical and radiological investigation of 121 children with cavernous transformation of the portal vein seen between 1986 and 2000, 8 presented with jaundice, pruritus, and/or raised serum aminotransferases and/or gamma glutamyl transpeptidase (gamma GT) activities. Each displayed dilation and narrowing of intra- and/or extrahepatic bile ducts. Surgical decompression of the portal system (portal-systemic or Rex anastomosis) resulted in the regression of the signs of cholestasis in all children. We conclude that children with portal vein obstruction may exhibit clinically significant cholestasis as a result of external compression of the bile duct by the cavernoma.

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