Chromosomal localization of muscle nicotinic acetylcholine receptor genes in the mouse

Odile Heidmann, Andrés Buonanno, Brigitte Geoffroy, Benoît Robert, Jean Louis Guénet, John P. Merlie, Jean Pierre Changeux

Résultats de recherche: Contribution à un journalArticleRevue par des pairs

72 Citations (Scopus)

Résumé

The chromosomal localization of the genes encoding the four subunits of muscle nicotinic receptor was determined by analyzing restriction fragment length polymorphisms between two mouse species Mus musculus domesticus (DBA/2) and Mus spretus (SPE). Analysis of the progeny of the interspecies mouse backcross (DBA/2 × SPE) × DBA/2 showed that the α-subunit gene cosegregates with the α-cardiac actin gene on chromosome 17, that the ß-subunit gene is located on chromosome 11, and that the γ-atid δ-subunit genes cosegregate and are located on chromosome 1.

langue originaleAnglais
Pages (de - à)866-868
Nombre de pages3
journalScience
Volume234
Numéro de publication4778
Les DOIs
étatPublié - 1 janv. 1986
Modification externeOui

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