TY - JOUR
T1 - Chromosomal translocations involving the IGH@ locus in B-cell precursor acute lymphoblastic leukemia
T2 - 29 new cases and a review of the literature
AU - Chapiro, Elise
AU - Radford-Weiss, Isabelle
AU - Cung, Hong Anh
AU - Dastugue, Nicole
AU - Nadal, Nathalie
AU - Taviaux, Sylvie
AU - Barin, Carole
AU - Struski, Stephanie
AU - Talmant, Pascaline
AU - Vandenberghe, Peter
AU - Mozziconacci, Marie Joelle
AU - Tigaud, Isabelle
AU - Lefebvre, Christine
AU - Penther, Dominique
AU - Bastard, Christian
AU - Lippert, Eric
AU - Mugneret, Francine
AU - Romana, Serge
AU - Bernard, Olivier A.
AU - Harrison, Christine J.
AU - Russell, Lisa J.
AU - Nguyen-Khac, Florence
PY - 2013/5/1
Y1 - 2013/5/1
N2 - Chromosomal translocations involving the immunoglobulin heavy chain locus (IGH@) are recurrent but rare in B-cell precursor acute lymphoblastic leukemia (BCP-ALL), and various partner genes have been described. Here, we report a new series of 29 cases of BCP-ALL with IGH@ translocations. The partner gene was identified by fluorescence in situ hybridization and/or molecular cloning in 20 patients. Members of the CEBP gene family (n = 11), BCL2 (n = 3), ID4 (n = 3), EPOR (n = 2), and TRA/D@ (n = 1) were identified and demonstrated by quantitative real-time reverse transcriptase-polymerase chain reaction to be markedly up-regulated. The present cases, added to those already reported, confirm the diversity of the partner genes, which, apart from BCL2, are specific to BCP-ALL. Collectively, patients with IGH@ translocations may represent a novel sub-group of BCP-ALL occurring in adolescents and young adults.
AB - Chromosomal translocations involving the immunoglobulin heavy chain locus (IGH@) are recurrent but rare in B-cell precursor acute lymphoblastic leukemia (BCP-ALL), and various partner genes have been described. Here, we report a new series of 29 cases of BCP-ALL with IGH@ translocations. The partner gene was identified by fluorescence in situ hybridization and/or molecular cloning in 20 patients. Members of the CEBP gene family (n = 11), BCL2 (n = 3), ID4 (n = 3), EPOR (n = 2), and TRA/D@ (n = 1) were identified and demonstrated by quantitative real-time reverse transcriptase-polymerase chain reaction to be markedly up-regulated. The present cases, added to those already reported, confirm the diversity of the partner genes, which, apart from BCL2, are specific to BCP-ALL. Collectively, patients with IGH@ translocations may represent a novel sub-group of BCP-ALL occurring in adolescents and young adults.
KW - B-cell progenitor acute lymphoblastic leukemia
KW - IGH@ translocations
UR - http://www.scopus.com/inward/record.url?scp=84881258981&partnerID=8YFLogxK
U2 - 10.1016/j.cancergen.2013.04.004
DO - 10.1016/j.cancergen.2013.04.004
M3 - Article
C2 - 23827691
AN - SCOPUS:84881258981
SN - 2210-7762
VL - 206
SP - 162
EP - 173
JO - Cancer Genetics
JF - Cancer Genetics
IS - 5
ER -