Chronic lymphocytic leukaemia genomics and the precision medicine era

Hussein Ghamlouch; Florence Nguyen-Khac; Olivier A. Bernard

doi:10.1111/bjh.14719

Chronic lymphocytic leukaemia genomics and the precision medicine era

Hussein Ghamlouch, Florence Nguyen-Khac, Olivier A. Bernard

Résultats de recherche: Contribution à un journal › Article 'review' › Revue par des pairs

12 Citations (Scopus)

Résumé

Massive genomic analyses have underscored the diversity of chronic lymphocytic leukaemia (CLL) between patients. Genetic heterogeneity of tumour clones within a patient may fuel tumour evolution. Several recurrently deregulated intra-cellular pathways are candidates for targeted therapies that are very promising and are dramatically changing clinical patients’ perspectives. In this review we present an overview of the genetic and epigenetic features of CLL and their clinical and biological implications.

langue originale	Anglais
Pages (de - à)	852-870
Nombre de pages	19
journal	British Journal of Haematology
Volume	178
Numéro de publication	6
Les DOIs	https://doi.org/10.1111/bjh.14719
état	Publié - 1 sept. 2017

Accès au document

10.1111/bjh.14719

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abstract = "Massive genomic analyses have underscored the diversity of chronic lymphocytic leukaemia (CLL) between patients. Genetic heterogeneity of tumour clones within a patient may fuel tumour evolution. Several recurrently deregulated intra-cellular pathways are candidates for targeted therapies that are very promising and are dramatically changing clinical patients{\textquoteright} perspectives. In this review we present an overview of the genetic and epigenetic features of CLL and their clinical and biological implications.",

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