Chronic lymphocytic leukemia: Time to go past genomics?

Damien Roos-Weil; Florence Nguyen-Khac; Olivier A. Bernard

doi:10.1002/ajh.24301

Chronic lymphocytic leukemia: Time to go past genomics?

Damien Roos-Weil, Florence Nguyen-Khac, Olivier A. Bernard

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

12 Citations (Scopus)

Résumé

Recent advances in massively parallel sequencing technologies have provided a detailed picture of the mutational landscape in CLL and underscored the vast degree of interpatient and intratumor heterogeneities. These studies have led to the characterization of novel putative driver genes and recurrently affected biological pathways, and to the modeling of CLL clonal evolution. We herein review selected aspects including recent advances in the biology of CLL and present cellular and biological processes involved in the development of CLL and potentially other mature B-cell lymphoproliferative neoplasms.

langue originale	Anglais
Pages (de - à)	518-528
Nombre de pages	11
journal	American Journal of Hematology
Volume	91
Numéro de publication	5
Les DOIs	https://doi.org/10.1002/ajh.24301
état	Publié - 1 mai 2016

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10.1002/ajh.24301

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title = "Chronic lymphocytic leukemia: Time to go past genomics?",

abstract = "Recent advances in massively parallel sequencing technologies have provided a detailed picture of the mutational landscape in CLL and underscored the vast degree of interpatient and intratumor heterogeneities. These studies have led to the characterization of novel putative driver genes and recurrently affected biological pathways, and to the modeling of CLL clonal evolution. We herein review selected aspects including recent advances in the biology of CLL and present cellular and biological processes involved in the development of CLL and potentially other mature B-cell lymphoproliferative neoplasms.",

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