Cisplatin resistance coupled to enhanced sensitivity to metabolic interventions

Maria Castedo; Florine Obrist; Guido Kroemer

doi:10.1080/23723556.2018.1526004

Cisplatin resistance coupled to enhanced sensitivity to metabolic interventions

Maria Castedo, Florine Obrist, Guido Kroemer

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

3 Citations (Scopus)

Résumé

Specific metabolic alterations have recently been observed in cisplatin-resistant cancers. As a result, cisplatin resistance can be overcome by co-administration of pyridoxine, and cisplatin-resistant cancer cells become exquisitely sensitive to killing by inhibitors of poly(ADP-ribose) polymerase, starvation, and antimetabolites targeting nucleotide biosynthesis.

langue originale	Anglais
Numéro d'article	e1526004
journal	Molecular and Cellular Oncology
Volume	5
Numéro de publication	6
Les DOIs	https://doi.org/10.1080/23723556.2018.1526004
état	Publié - 2 nov. 2018

Accès au document

10.1080/23723556.2018.1526004

Autres fichiers et liens

Lien vers la publication dans Scopus

Contient cette citation

@article{54370fd26df744bc808e78c9b29766c6,

title = "Cisplatin resistance coupled to enhanced sensitivity to metabolic interventions",

abstract = "Specific metabolic alterations have recently been observed in cisplatin-resistant cancers. As a result, cisplatin resistance can be overcome by co-administration of pyridoxine, and cisplatin-resistant cancer cells become exquisitely sensitive to killing by inhibitors of poly(ADP-ribose) polymerase, starvation, and antimetabolites targeting nucleotide biosynthesis.",

keywords = "DNA damage response, chemotherapy, non-small cell lung cancer",

author = "Maria Castedo and Florine Obrist and Guido Kroemer",

note = "Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.",

year = "2018",

month = nov,

day = "2",

doi = "10.1080/23723556.2018.1526004",

language = "English",

volume = "5",

journal = "Molecular and Cellular Oncology",

issn = "2372-3556",

number = "6",

}

TY - JOUR

T1 - Cisplatin resistance coupled to enhanced sensitivity to metabolic interventions

AU - Castedo, Maria

AU - Obrist, Florine

AU - Kroemer, Guido

PY - 2018/11/2

Y1 - 2018/11/2

N2 - Specific metabolic alterations have recently been observed in cisplatin-resistant cancers. As a result, cisplatin resistance can be overcome by co-administration of pyridoxine, and cisplatin-resistant cancer cells become exquisitely sensitive to killing by inhibitors of poly(ADP-ribose) polymerase, starvation, and antimetabolites targeting nucleotide biosynthesis.

AB - Specific metabolic alterations have recently been observed in cisplatin-resistant cancers. As a result, cisplatin resistance can be overcome by co-administration of pyridoxine, and cisplatin-resistant cancer cells become exquisitely sensitive to killing by inhibitors of poly(ADP-ribose) polymerase, starvation, and antimetabolites targeting nucleotide biosynthesis.

KW - DNA damage response

KW - chemotherapy

KW - non-small cell lung cancer

UR - http://www.scopus.com/inward/record.url?scp=85054789947&partnerID=8YFLogxK

U2 - 10.1080/23723556.2018.1526004

DO - 10.1080/23723556.2018.1526004

M3 - Article

AN - SCOPUS:85054789947

SN - 2372-3556

VL - 5

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 6

M1 - e1526004

ER -