Clinical evaluation of a new lipid-based delivery system for intravenous administration of amphotericin B

D. Caillot, P. Chavanet, O. Casasnovas, E. Solary, G. Zanetta, M. Buisson, O. Wagner, B. Cuisenier, A. Bonnin, P. Camerlynck, H. Portier, H. Guy

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Résumé

In a retrospective study a new lipid-based delivery system for administration of amphotericin B was evaluated in 26 treatment courses in 22 patients. Amphotericin B was given by infusion diluted in either the lipid solution (1 mg/kg/d; 13 courses) or dextrose (0.92 mg/kg/d; 13 courses). No differences were noted in the serum pharmacokinetics. Fever or rigors were observed in 6 of 13 courses in the conventional amphotericin B group versus none in the lipid amphotericin B group (p=0.007). Four of 13 courses of treatment were discontinued due to adverse effects in the conventional amphotericin B group compared to none in the other group (p=0.048). In the lipid amphotericin B group the decrease in creatinine clearance was significantly lower on the fourth day of treatment (p=0.04) and significantly fewer patients had a decrease of more than 25 % in creatinine clearance on the sixth day (4/12 vs 9/11 p=0.02). These preliminary findings suggest that this lipid amphotericin B formulation is well tolerated with few nephrotoxic effects.

langue originaleAnglais
Pages (de - à)722-725
Nombre de pages4
journalEuropean Journal of Clinical Microbiology & Infectious Diseases
Volume11
Numéro de publication8
Les DOIs
étatPublié - 1 août 1992
Modification externeOui

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