Clinical Response to Induction Chemotherapy Predicts Outcome after Combined-Modality Therapy in Inflammatory Breast Cancer

Mauro Loi, Ariane Dunant, Sahar Ghith, Almudena Maria Cascales-Garcia, Chafika Mazouni, Barbara Pistilli, Marie Christine Mathieu, Eric Deutsch, Rodrigo Arriagada, Sofia Rivera

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    3 Citations (Scopus)

    Résumé

    Purpose: To assess predictors of outcome in a cohort of Inflammatory Breast Cancer (IBC) patients receiving induction chemotherapy followed by local treatment. Methods: We retrospectively reviewed 95 non-metastatic IBC patient files. Results: Complete clinical response (cCR) was obtained in 15 (16%) patients. Median follow up was 13.4 years (IC95%: 10.4–14.6). Loco-regional control (LC), disease-free survival (DFS), and overall survival (OS) at 5 years were 85%, 41%, and 55%, respectively; cCR was associated with better DFS and OS in multivariate analyses adjusted for age (p = 0.02). Conclusions: Clinical response to upfront chemotherapy predicts the outcome of patients affected by IBC.

    langue originaleAnglais
    Pages (de - à)29-38
    Nombre de pages10
    journalCancer Investigation
    Volume37
    Numéro de publication1
    Les DOIs
    étatPublié - 2 janv. 2019

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