Clinically relevant GABARAP deficiency abrogates bortezomib-induced immunogenic cell death in multiple myeloma

Liwei Zhao, Zhe Shen, Guido Kroemer, Oliver Kepp

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    Résumé

    Recently, it was revealed that the high-risk, poor-prognosis downregulation of GABA type A receptor-associated protein (GABARAP) causes a defect in both autophagy and surface exposure of calreticulin (CALR) in multiple myeloma (MM) cells responding to bortezomib. Hence, GABARAP-defective MM cells fail to undergo immunogenic cell death.

    langue originaleAnglais
    Numéro d'article2360275
    journalOncoImmunology
    Volume13
    Numéro de publication1
    Les DOIs
    étatPublié - 1 janv. 2024

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