Clinically relevant GABARAP deficiency abrogates bortezomib-induced immunogenic cell death in multiple myeloma

Liwei Zhao; Zhe Shen; Guido Kroemer; Oliver Kepp

doi:10.1080/2162402X.2024.2360275

Clinically relevant GABARAP deficiency abrogates bortezomib-induced immunogenic cell death in multiple myeloma

Liwei Zhao, Zhe Shen, Guido Kroemer, Oliver Kepp

Résultats de recherche: Contribution à un journal › !!Comment/debate

Résumé

Recently, it was revealed that the high-risk, poor-prognosis downregulation of GABA type A receptor-associated protein (GABARAP) causes a defect in both autophagy and surface exposure of calreticulin (CALR) in multiple myeloma (MM) cells responding to bortezomib. Hence, GABARAP-defective MM cells fail to undergo immunogenic cell death.

langue originale	Anglais
Numéro d'article	2360275
journal	OncoImmunology
Volume	13
Numéro de publication	1
Les DOIs	https://doi.org/10.1080/2162402X.2024.2360275
état	Publié - 1 janv. 2024
Modification externe	Oui

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10.1080/2162402X.2024.2360275

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title = "Clinically relevant GABARAP deficiency abrogates bortezomib-induced immunogenic cell death in multiple myeloma",

abstract = "Recently, it was revealed that the high-risk, poor-prognosis downregulation of GABA type A receptor-associated protein (GABARAP) causes a defect in both autophagy and surface exposure of calreticulin (CALR) in multiple myeloma (MM) cells responding to bortezomib. Hence, GABARAP-defective MM cells fail to undergo immunogenic cell death.",

keywords = "Immunotherapy, autophagy, danger associated molecular pattern, phagocytosis",

author = "Liwei Zhao and Zhe Shen and Guido Kroemer and Oliver Kepp",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.",

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doi = "10.1080/2162402X.2024.2360275",

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AU - Zhao, Liwei

AU - Shen, Zhe

AU - Kroemer, Guido

AU - Kepp, Oliver

PY - 2024/1/1

Y1 - 2024/1/1

N2 - Recently, it was revealed that the high-risk, poor-prognosis downregulation of GABA type A receptor-associated protein (GABARAP) causes a defect in both autophagy and surface exposure of calreticulin (CALR) in multiple myeloma (MM) cells responding to bortezomib. Hence, GABARAP-defective MM cells fail to undergo immunogenic cell death.

AB - Recently, it was revealed that the high-risk, poor-prognosis downregulation of GABA type A receptor-associated protein (GABARAP) causes a defect in both autophagy and surface exposure of calreticulin (CALR) in multiple myeloma (MM) cells responding to bortezomib. Hence, GABARAP-defective MM cells fail to undergo immunogenic cell death.

KW - Immunotherapy

KW - autophagy

KW - danger associated molecular pattern

KW - phagocytosis

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DO - 10.1080/2162402X.2024.2360275

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