Combined effects of smoking and HPV16 in oropharyngeal cancer

Devasena Anantharaman; David C. Muller; Pagona Lagiou; Wolfgang Ahrens; Ivana Holcátová; Franco Merletti; Kristina Kjærheim; Jerry Polesel; Lorenzo Simonato; Cristina Canova; Xavier Castellsague; Tatiana V. Macfarlane; Ariana Znaor; Peter Thomson; Max Robinson; David I. Conway; Claire M. Healy; Anne Tjønneland; Ulla Westin; Johanna Ekström; Jenny Chang-Claude; Rudolf Kaaks; Kim Overvad; Dagmar Drogan; Göran Hallmans; Göran Laurell; H. B. Bueno-de-Mesquita; Petra H. Peeters; Antonio Agudo; Nerea Larrañaga; Ruth C. Travis; Domenico Palli; Aurelio Barricarte; Antonia Trichopoulou; Saitakis George; Dimitrios Trichopoulos; J. Ramón Quirós; Sara Grioni; Carlotta Sacerdote; Carmen Navarro; María José Sánchez; Rosario Tumino; Gianluca Severi; Marie Christine Boutron-Ruault; Francoise Clavel-Chapelon; Salvatore Panico; Elisabete Weiderpass; Eiliv Lund; Inger T. Gram; Elio Riboli; Michael Pawlita; Tim Waterboer; Aimée R. Kreimer; Mattias Johansson; Paul Brennan

doi:10.1093/ije/dyw069

Combined effects of smoking and HPV16 in oropharyngeal cancer

Devasena Anantharaman, David C. Muller, Pagona Lagiou, Wolfgang Ahrens, Ivana Holcátová, Franco Merletti, Kristina Kjærheim, Jerry Polesel, Lorenzo Simonato, Cristina Canova, Xavier Castellsague, Tatiana V. Macfarlane, Ariana Znaor, Peter Thomson, Max Robinson, David I. Conway, Claire M. Healy, Anne Tjønneland, Ulla Westin, Johanna EkströmJenny Chang-Claude, Rudolf Kaaks, Kim Overvad, Dagmar Drogan, Göran Hallmans, Göran Laurell, H. B. Bueno-de-Mesquita, Petra H. Peeters, Antonio Agudo, Nerea Larrañaga, Ruth C. Travis, Domenico Palli, Aurelio Barricarte, Antonia Trichopoulou, Saitakis George, Dimitrios Trichopoulos, J. Ramón Quirós, Sara Grioni, Carlotta Sacerdote, Carmen Navarro, María José Sánchez, Rosario Tumino, Gianluca Severi, Marie Christine Boutron-Ruault, Francoise Clavel-Chapelon, Salvatore Panico, Elisabete Weiderpass, Eiliv Lund, Inger T. Gram, Elio Riboli, Michael Pawlita, Tim Waterboer, Aimée R. Kreimer, Mattias Johansson, Paul Brennan

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

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Résumé

Background: Although smoking and HPV infection are recognized as important risk factors for oropharyngeal cancer, how their joint exposure impacts on oropharyngeal cancer risk is unclear. Specifically, whether smoking confers any additional risk to HPVpositive oropharyngeal cancer is not understood. Methods: Using HPV serology as a marker of HPV-related cancer, we examined the interaction between smoking and HPV16 in 459 oropharyngeal (and 1445 oral cavity and laryngeal) cancer patients and 3024 control participants from two large European multicentre studies. Odds ratios and credible intervals [CrI], adjusted for potential confounders, were estimated using Bayesian logistic regression. Results: Both smoking [odds ratio (OR [CrI]: 6.82 [4.52, 10.29]) and HPV seropositivity (OR [CrI]: 235.69 [99.95, 555.74]) were independently associated with oropharyngeal cancer. The joint association of smoking and HPV seropositivity was consistent with that expected on the additive scale (synergy index [CrI]: 1.32 [0.51, 3.45]), suggesting they act as independent risk factors for oropharyngeal cancer. Conclusions: Smoking was consistently associated with increase in oropharyngeal cancer risk in models stratified by HPV16 seropositivity. In addition, we report that the prevalence of oropharyngeal cancer increases with smoking for both HPV16-positive and HPV16-negative persons. The impact of smoking on HPV16-positive oropharyngeal cancer highlights the continued need for smoking cessation programmes for primary prevention of head and neck cancer.

langue originale	Anglais
Pages (de - à)	752-761
Nombre de pages	10
journal	International Journal of Epidemiology
Volume	45
Numéro de publication	3
Les DOIs	https://doi.org/10.1093/ije/dyw069
état	Publié - 1 juin 2016
Modification externe	Oui

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10.1093/ije/dyw069

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Anantharaman, D., Muller, D. C., Lagiou, P., Ahrens, W., Holcátová, I., Merletti, F., Kjærheim, K., Polesel, J., Simonato, L., Canova, C., Castellsague, X., Macfarlane, T. V., Znaor, A., Thomson, P., Robinson, M., Conway, D. I., Healy, C. M., Tjønneland, A., Westin, U., ... Brennan, P. (2016). Combined effects of smoking and HPV16 in oropharyngeal cancer. International Journal of Epidemiology, 45(3), 752-761. https://doi.org/10.1093/ije/dyw069

@article{7a73157455ec44bf88406be7406ba6a3,

title = "Combined effects of smoking and HPV16 in oropharyngeal cancer",

abstract = "Background: Although smoking and HPV infection are recognized as important risk factors for oropharyngeal cancer, how their joint exposure impacts on oropharyngeal cancer risk is unclear. Specifically, whether smoking confers any additional risk to HPVpositive oropharyngeal cancer is not understood. Methods: Using HPV serology as a marker of HPV-related cancer, we examined the interaction between smoking and HPV16 in 459 oropharyngeal (and 1445 oral cavity and laryngeal) cancer patients and 3024 control participants from two large European multicentre studies. Odds ratios and credible intervals [CrI], adjusted for potential confounders, were estimated using Bayesian logistic regression. Results: Both smoking [odds ratio (OR [CrI]: 6.82 [4.52, 10.29]) and HPV seropositivity (OR [CrI]: 235.69 [99.95, 555.74]) were independently associated with oropharyngeal cancer. The joint association of smoking and HPV seropositivity was consistent with that expected on the additive scale (synergy index [CrI]: 1.32 [0.51, 3.45]), suggesting they act as independent risk factors for oropharyngeal cancer. Conclusions: Smoking was consistently associated with increase in oropharyngeal cancer risk in models stratified by HPV16 seropositivity. In addition, we report that the prevalence of oropharyngeal cancer increases with smoking for both HPV16-positive and HPV16-negative persons. The impact of smoking on HPV16-positive oropharyngeal cancer highlights the continued need for smoking cessation programmes for primary prevention of head and neck cancer.",

keywords = "Head and neck cancer risk, Human papillomavirus, Interaction, Oropharynx cancer, Tobacco smoking",

author = "Devasena Anantharaman and Muller, {David C.} and Pagona Lagiou and Wolfgang Ahrens and Ivana Holc{\'a}tov{\'a} and Franco Merletti and Kristina Kj{\ae}rheim and Jerry Polesel and Lorenzo Simonato and Cristina Canova and Xavier Castellsague and Macfarlane, {Tatiana V.} and Ariana Znaor and Peter Thomson and Max Robinson and Conway, {David I.} and Healy, {Claire M.} and Anne Tj{\o}nneland and Ulla Westin and Johanna Ekstr{\"o}m and Jenny Chang-Claude and Rudolf Kaaks and Kim Overvad and Dagmar Drogan and G{\"o}ran Hallmans and G{\"o}ran Laurell and Bueno-de-Mesquita, {H. B.} and Peeters, {Petra H.} and Antonio Agudo and Nerea Larra{\~n}aga and Travis, {Ruth C.} and Domenico Palli and Aurelio Barricarte and Antonia Trichopoulou and Saitakis George and Dimitrios Trichopoulos and Quir{\'o}s, {J. Ram{\'o}n} and Sara Grioni and Carlotta Sacerdote and Carmen Navarro and S{\'a}nchez, {Mar{\'i}a Jos{\'e}} and Rosario Tumino and Gianluca Severi and Boutron-Ruault, {Marie Christine} and Francoise Clavel-Chapelon and Salvatore Panico and Elisabete Weiderpass and Eiliv Lund and Gram, {Inger T.} and Elio Riboli and Michael Pawlita and Tim Waterboer and Kreimer, {Aim{\'e}e R.} and Mattias Johansson and Paul Brennan",

note = "Publisher Copyright: {\textcopyright} The Author 2016.",

year = "2016",

month = jun,

day = "1",

doi = "10.1093/ije/dyw069",

language = "English",

volume = "45",

pages = "752--761",

journal = "International Journal of Epidemiology",

issn = "0300-5771",

number = "3",

}

Anantharaman, D, Muller, DC, Lagiou, P, Ahrens, W, Holcátová, I, Merletti, F, Kjærheim, K, Polesel, J, Simonato, L, Canova, C, Castellsague, X, Macfarlane, TV, Znaor, A, Thomson, P, Robinson, M, Conway, DI, Healy, CM, Tjønneland, A, Westin, U, Ekström, J, Chang-Claude, J, Kaaks, R, Overvad, K, Drogan, D, Hallmans, G, Laurell, G, Bueno-de-Mesquita, HB, Peeters, PH, Agudo, A, Larrañaga, N, Travis, RC, Palli, D, Barricarte, A, Trichopoulou, A, George, S, Trichopoulos, D, Quirós, JR, Grioni, S, Sacerdote, C, Navarro, C, Sánchez, MJ, Tumino, R, Severi, G, Boutron-Ruault, MC, Clavel-Chapelon, F, Panico, S, Weiderpass, E, Lund, E, Gram, IT, Riboli, E, Pawlita, M, Waterboer, T, Kreimer, AR, Johansson, M & Brennan, P 2016, 'Combined effects of smoking and HPV16 in oropharyngeal cancer', International Journal of Epidemiology, VOL. 45, Numéro 3, p. 752-761. https://doi.org/10.1093/ije/dyw069

TY - JOUR

T1 - Combined effects of smoking and HPV16 in oropharyngeal cancer

AU - Anantharaman, Devasena

AU - Muller, David C.

AU - Lagiou, Pagona

AU - Ahrens, Wolfgang

AU - Holcátová, Ivana

AU - Merletti, Franco

AU - Kjærheim, Kristina

AU - Polesel, Jerry

AU - Simonato, Lorenzo

AU - Canova, Cristina

AU - Castellsague, Xavier

AU - Macfarlane, Tatiana V.

AU - Znaor, Ariana

AU - Thomson, Peter

AU - Robinson, Max

AU - Conway, David I.

AU - Healy, Claire M.

AU - Tjønneland, Anne

AU - Westin, Ulla

AU - Ekström, Johanna

AU - Chang-Claude, Jenny

AU - Kaaks, Rudolf

AU - Overvad, Kim

AU - Drogan, Dagmar

AU - Hallmans, Göran

AU - Laurell, Göran

AU - Bueno-de-Mesquita, H. B.

AU - Peeters, Petra H.

AU - Agudo, Antonio

AU - Larrañaga, Nerea

AU - Travis, Ruth C.

AU - Palli, Domenico

AU - Barricarte, Aurelio

AU - Trichopoulou, Antonia

AU - George, Saitakis

AU - Trichopoulos, Dimitrios

AU - Quirós, J. Ramón

AU - Grioni, Sara

AU - Sacerdote, Carlotta

AU - Navarro, Carmen

AU - Sánchez, María José

AU - Tumino, Rosario

AU - Severi, Gianluca

AU - Boutron-Ruault, Marie Christine

AU - Clavel-Chapelon, Francoise

AU - Panico, Salvatore

AU - Weiderpass, Elisabete

AU - Lund, Eiliv

AU - Gram, Inger T.

AU - Riboli, Elio

AU - Pawlita, Michael

AU - Waterboer, Tim

AU - Kreimer, Aimée R.

AU - Johansson, Mattias

AU - Brennan, Paul

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Background: Although smoking and HPV infection are recognized as important risk factors for oropharyngeal cancer, how their joint exposure impacts on oropharyngeal cancer risk is unclear. Specifically, whether smoking confers any additional risk to HPVpositive oropharyngeal cancer is not understood. Methods: Using HPV serology as a marker of HPV-related cancer, we examined the interaction between smoking and HPV16 in 459 oropharyngeal (and 1445 oral cavity and laryngeal) cancer patients and 3024 control participants from two large European multicentre studies. Odds ratios and credible intervals [CrI], adjusted for potential confounders, were estimated using Bayesian logistic regression. Results: Both smoking [odds ratio (OR [CrI]: 6.82 [4.52, 10.29]) and HPV seropositivity (OR [CrI]: 235.69 [99.95, 555.74]) were independently associated with oropharyngeal cancer. The joint association of smoking and HPV seropositivity was consistent with that expected on the additive scale (synergy index [CrI]: 1.32 [0.51, 3.45]), suggesting they act as independent risk factors for oropharyngeal cancer. Conclusions: Smoking was consistently associated with increase in oropharyngeal cancer risk in models stratified by HPV16 seropositivity. In addition, we report that the prevalence of oropharyngeal cancer increases with smoking for both HPV16-positive and HPV16-negative persons. The impact of smoking on HPV16-positive oropharyngeal cancer highlights the continued need for smoking cessation programmes for primary prevention of head and neck cancer.

AB - Background: Although smoking and HPV infection are recognized as important risk factors for oropharyngeal cancer, how their joint exposure impacts on oropharyngeal cancer risk is unclear. Specifically, whether smoking confers any additional risk to HPVpositive oropharyngeal cancer is not understood. Methods: Using HPV serology as a marker of HPV-related cancer, we examined the interaction between smoking and HPV16 in 459 oropharyngeal (and 1445 oral cavity and laryngeal) cancer patients and 3024 control participants from two large European multicentre studies. Odds ratios and credible intervals [CrI], adjusted for potential confounders, were estimated using Bayesian logistic regression. Results: Both smoking [odds ratio (OR [CrI]: 6.82 [4.52, 10.29]) and HPV seropositivity (OR [CrI]: 235.69 [99.95, 555.74]) were independently associated with oropharyngeal cancer. The joint association of smoking and HPV seropositivity was consistent with that expected on the additive scale (synergy index [CrI]: 1.32 [0.51, 3.45]), suggesting they act as independent risk factors for oropharyngeal cancer. Conclusions: Smoking was consistently associated with increase in oropharyngeal cancer risk in models stratified by HPV16 seropositivity. In addition, we report that the prevalence of oropharyngeal cancer increases with smoking for both HPV16-positive and HPV16-negative persons. The impact of smoking on HPV16-positive oropharyngeal cancer highlights the continued need for smoking cessation programmes for primary prevention of head and neck cancer.

KW - Head and neck cancer risk

KW - Human papillomavirus

KW - Interaction

KW - Oropharynx cancer

KW - Tobacco smoking

UR - http://www.scopus.com/inward/record.url?scp=84995799009&partnerID=8YFLogxK

U2 - 10.1093/ije/dyw069

DO - 10.1093/ije/dyw069

M3 - Article

C2 - 27197530

AN - SCOPUS:84995799009

SN - 0300-5771

VL - 45

SP - 752

EP - 761

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

IS - 3

ER -