Competitive repair pathways in immunoglobulin gene hypermutation

Claude Agnès Reynaud, Frédéric Delbos, Ahmad Faili, Quentin Guéranger, Said Aoufouchi, Jean Claude Weill

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    26 Citations (Scopus)

    Résumé

    This review focuses on the contribution of translesion DNA polymerases to immunoglobulin gene hypermutation, in particular on the roles of DNA polymerase eta (Polη) in the generation of mutations at A/T bases from the initial cytosine-targeted activation-induced cytidine deaminase (AID)-mediated deamination event, and of Polκ, an enzyme of the same polymerase family, used as a substitute when Polη is absent. The proposition that the UNG uracil glycosylase and the MSH2-MSH6 mismatch recognition complex are two competitive rather than alternative pathways in the processing of uracils generated by AID is further discussed.

    langue originaleAnglais
    Pages (de - à)613-619
    Nombre de pages7
    journalPhilosophical Transactions of the Royal Society B: Biological Sciences
    Volume364
    Numéro de publication1517
    Les DOIs
    étatPublié - 12 mars 2009

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