TY - JOUR
T1 - Competitive repair pathways in immunoglobulin gene hypermutation
AU - Reynaud, Claude Agnès
AU - Delbos, Frédéric
AU - Faili, Ahmad
AU - Guéranger, Quentin
AU - Aoufouchi, Said
AU - Weill, Jean Claude
PY - 2009/3/12
Y1 - 2009/3/12
N2 - This review focuses on the contribution of translesion DNA polymerases to immunoglobulin gene hypermutation, in particular on the roles of DNA polymerase eta (Polη) in the generation of mutations at A/T bases from the initial cytosine-targeted activation-induced cytidine deaminase (AID)-mediated deamination event, and of Polκ, an enzyme of the same polymerase family, used as a substitute when Polη is absent. The proposition that the UNG uracil glycosylase and the MSH2-MSH6 mismatch recognition complex are two competitive rather than alternative pathways in the processing of uracils generated by AID is further discussed.
AB - This review focuses on the contribution of translesion DNA polymerases to immunoglobulin gene hypermutation, in particular on the roles of DNA polymerase eta (Polη) in the generation of mutations at A/T bases from the initial cytosine-targeted activation-induced cytidine deaminase (AID)-mediated deamination event, and of Polκ, an enzyme of the same polymerase family, used as a substitute when Polη is absent. The proposition that the UNG uracil glycosylase and the MSH2-MSH6 mismatch recognition complex are two competitive rather than alternative pathways in the processing of uracils generated by AID is further discussed.
KW - DNA polymerase eta (Polη)
KW - Mismatch repair
KW - Translesion DNA synthesis
UR - http://www.scopus.com/inward/record.url?scp=60049087517&partnerID=8YFLogxK
U2 - 10.1098/rstb.2008.0206
DO - 10.1098/rstb.2008.0206
M3 - Article
C2 - 19010770
AN - SCOPUS:60049087517
SN - 0962-8436
VL - 364
SP - 613
EP - 619
JO - Philosophical Transactions of the Royal Society B: Biological Sciences
JF - Philosophical Transactions of the Royal Society B: Biological Sciences
IS - 1517
ER -