Comprehensive review into the challenges of gastrointestinal tumors in the gulf and levant countries

Fadi Farhat, Abdulaziz Al Farsi, Ahmed Mohieldin, Bassim Al Bahrani, Eman Sbaity, Hassan Jaffar, Joseph Kattan, Kakil Rasul, Khairallah Saad, Tarek Assi, Waleed El Morsi, Rafid A. Abood

Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

4 Citations (Scopus)

Résumé

Although gastrointestinal stromal tumors (GISTs) are rare, with an incidence of 1/100000 per year, they are the most common sarcomas in the peritoneal cavity. Despite considerable progress in the diagnosis and treatment of GIST, about half of all patients are estimated to experience recurrence. With only two drugs, sunitinib and regorafenib, approved by the Food and Drug Administration, selecting treatment options after imatinib failure and coordinating multidisciplinary care remain challenging. In addition, physicians across the Middle East face some additional and unique challenges such as lack of published local data from clinical trials, national disease registries and regional scientific research, limited access to treatment, lack of standardization of care, and limited access to mutational analysis. Although global guidelines set a framework for the management of GIST, there are no standard local guidelines to guide clinical practice in a resource-limited environment. Therefore, a group of 11 experienced medical oncologists from across the Gulf and Levant region, part of the Rare Tumors Gastrointestinal Group, met over a period of one year to conduct a narrative review of the management of GIST and to describe regional challenges and gaps in patient management as an essential step to proposing local clinical practice recommendations.

langue originaleAnglais
Pages (de - à)487-503
Nombre de pages17
journalWorld Journal of Clinical Cases
Volume8
Numéro de publication3
Les DOIs
étatPublié - 1 févr. 2020
Modification externeOui

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