TY - JOUR
T1 - Cone-beam CT angiography for determination of tumor-feeding vessels during chemoembolization of liver tumors
T2 - Comparison of conventional and dedicated-software analysis
AU - Ronot, Maxime
AU - Abdel-Rehim, Mohamed
AU - Hakimé, Antoine
AU - Kuoch, Viseth
AU - Roux, Marion
AU - Chiaradia, Mélanie
AU - Vilgrain, Valérie
AU - De Baere, Thierry
AU - Deschamps, Frédéric
N1 - Publisher Copyright:
© 2016 SIR.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Purpose To compare the ability of dedicated software and conventional cone-beam computed tomography (CT) analysis to identify tumor-feeding vessels in hypervascular liver tumors treated with chemoembolization. Material and Methods Between January 2012 and January 2013, 45 patients (32 men, mean age of 61 y; range, 27-85 y) were enrolled, and 66 tumors were treated (mean, 32 mm ± 18; range, 10-81 mm) with conventional chemoembolization with arterial cone-beam CT. Data were independently analyzed by six interventional radiologists with standard postprocessing software, a computer-aided analysis with FlightPlan for liver (FPFL; ie, "raw FPFL"), and a review of this computer-aided FPFL analysis ("reviewed FPFL"). Analyses were compared with a reference reading established by two study supervisors in consensus who had access to all imaging data. Sensitivities, positive predictive values (PPVs), and false-positive (FP) ratios were compared by McNemar, χ2, and Fisher exact tests. Analysis durations were compared by Mann-Whitney test, and interreader agreement was assessed. Results Reference reading identified 179 feeder vessels. The sensitivity of raw FPFL was significantly higher than those of reviewed FPFL and conventional analyses (90.9% vs 83.2% and 82.1%; P <.0001), with lower PPV (82.9% vs 91.2% and 90.6%, respectively; P <.0001), higher FP ratio (17.1% vs 9.4% and 8.8%, respectively; P <.0001), and greater interreader agreement (92% vs 80% and 79%, respectively; P <.0001). Reviewed FPFL analysis took significantly longer than both other analyses (P <.0001). Conclusions The FPFL analysis software enabled a fast, accurate, and sensitive detection of tumor feeder vessels.
AB - Purpose To compare the ability of dedicated software and conventional cone-beam computed tomography (CT) analysis to identify tumor-feeding vessels in hypervascular liver tumors treated with chemoembolization. Material and Methods Between January 2012 and January 2013, 45 patients (32 men, mean age of 61 y; range, 27-85 y) were enrolled, and 66 tumors were treated (mean, 32 mm ± 18; range, 10-81 mm) with conventional chemoembolization with arterial cone-beam CT. Data were independently analyzed by six interventional radiologists with standard postprocessing software, a computer-aided analysis with FlightPlan for liver (FPFL; ie, "raw FPFL"), and a review of this computer-aided FPFL analysis ("reviewed FPFL"). Analyses were compared with a reference reading established by two study supervisors in consensus who had access to all imaging data. Sensitivities, positive predictive values (PPVs), and false-positive (FP) ratios were compared by McNemar, χ2, and Fisher exact tests. Analysis durations were compared by Mann-Whitney test, and interreader agreement was assessed. Results Reference reading identified 179 feeder vessels. The sensitivity of raw FPFL was significantly higher than those of reviewed FPFL and conventional analyses (90.9% vs 83.2% and 82.1%; P <.0001), with lower PPV (82.9% vs 91.2% and 90.6%, respectively; P <.0001), higher FP ratio (17.1% vs 9.4% and 8.8%, respectively; P <.0001), and greater interreader agreement (92% vs 80% and 79%, respectively; P <.0001). Reviewed FPFL analysis took significantly longer than both other analyses (P <.0001). Conclusions The FPFL analysis software enabled a fast, accurate, and sensitive detection of tumor feeder vessels.
UR - http://www.scopus.com/inward/record.url?scp=84952873836&partnerID=8YFLogxK
U2 - 10.1016/j.jvir.2015.09.010
DO - 10.1016/j.jvir.2015.09.010
M3 - Article
C2 - 26549371
AN - SCOPUS:84952873836
SN - 1051-0443
VL - 27
SP - 32
EP - 38
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
IS - 1
ER -