Conservation des propriétés allostériques de la protéine réceptrice de l'acétylcholine en solution détergente sans addition de lipides.

T. Heidmann; J. B. Cuisinier; J. P. Changeux

Conservation des propriétés allostériques de la protéine réceptrice de l'acétylcholine en solution détergente sans addition de lipides.

T. Heidmann, J. B. Cuisinier, J. P. Changeux

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4 Citations (Scopus)

Résumé

Solubilization by Na cholate of acetylcholine receptor-rich membrane fragments from Torpedo marmorata, followed by exchange of NA cholate by the neutral detergent "Tween 80" yields the receptor protein in its 9 S soluble light form; under these conditions, without adding lipids, the receptor protein conserves its characteristic binding properties for the fluorescent agonist Dns-C6-Cho as followed by fast kinetic techniques, and the allosteric regulation by non-competitive blockers.

Titre traduit de la contribution	Preservation of the allosteric properties of the protein receptor for acetylcholine in detergent solution without addition of lipids
langue originale	Français
Pages (de - à)	13-15
Nombre de pages	3
journal	Comptes Rendus de l'Academie des Sciences - Serie III
Volume	292
Numéro de publication	1
état	Publié - 5 janv. 1981

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@article{c6f67d31b20e47ce9693c891cfc2b853,

title = "Conservation des propri{\'e}t{\'e}s allost{\'e}riques de la prot{\'e}ine r{\'e}ceptrice de l'ac{\'e}tylcholine en solution d{\'e}tergente sans addition de lipides.",

abstract = "Solubilization by Na cholate of acetylcholine receptor-rich membrane fragments from Torpedo marmorata, followed by exchange of NA cholate by the neutral detergent {"}Tween 80{"} yields the receptor protein in its 9 S soluble light form; under these conditions, without adding lipids, the receptor protein conserves its characteristic binding properties for the fluorescent agonist Dns-C6-Cho as followed by fast kinetic techniques, and the allosteric regulation by non-competitive blockers.",

author = "T. Heidmann and Cuisinier, {J. B.} and Changeux, {J. P.}",

year = "1981",

month = jan,

day = "5",

language = "Fran{\c c}ais",

volume = "292",

pages = "13--15",

journal = "Comptes Rendus de l'Academie des Sciences - Serie III",

issn = "0249-6313",

number = "1",

}

Conservation des propriétés allostériques de la protéine réceptrice de l'acétylcholine en solution détergente sans addition de lipides. / Heidmann, T.; Cuisinier, J. B.; Changeux, J. P.
Dans: Comptes Rendus de l'Academie des Sciences - Serie III, Vol 292, Numéro 1, 05.01.1981, p. 13-15.

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

TY - JOUR

T1 - Conservation des propriétés allostériques de la protéine réceptrice de l'acétylcholine en solution détergente sans addition de lipides.

AU - Heidmann, T.

AU - Cuisinier, J. B.

AU - Changeux, J. P.

PY - 1981/1/5

Y1 - 1981/1/5

N2 - Solubilization by Na cholate of acetylcholine receptor-rich membrane fragments from Torpedo marmorata, followed by exchange of NA cholate by the neutral detergent "Tween 80" yields the receptor protein in its 9 S soluble light form; under these conditions, without adding lipids, the receptor protein conserves its characteristic binding properties for the fluorescent agonist Dns-C6-Cho as followed by fast kinetic techniques, and the allosteric regulation by non-competitive blockers.

AB - Solubilization by Na cholate of acetylcholine receptor-rich membrane fragments from Torpedo marmorata, followed by exchange of NA cholate by the neutral detergent "Tween 80" yields the receptor protein in its 9 S soluble light form; under these conditions, without adding lipids, the receptor protein conserves its characteristic binding properties for the fluorescent agonist Dns-C6-Cho as followed by fast kinetic techniques, and the allosteric regulation by non-competitive blockers.

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M3 - Article

C2 - 6786766

AN - SCOPUS:0010263615

SN - 0249-6313

VL - 292

SP - 13

EP - 15

JO - Comptes Rendus de l'Academie des Sciences - Serie III

JF - Comptes Rendus de l'Academie des Sciences - Serie III

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