Contrast enhancement in 1p/19q-codeleted anaplastic oligodendrogliomas is associated with 9p loss, genomic instability, and angiogenic gene expression

German Reyes-Botero; Caroline Dehais; Ahmed Idbaih; Nadine Martin-Duverneuil; Marion Lahutte; Catherine Carpentier; Eric Letouzé; Olivier Chinot; Hugues Loiseau; Jerome Honnorat; Carole Ramirez; Elisabeth Moyal; Dominique Figarella-Branger; François Ducray; Christine Desenclos; Henri Sevestre; Philippe Menei; Sophie Michalak; Edmond Al Nader; Joel Godard; Gabriel Viennet; Antoine Carpentier; Sandrine Eimer; Phong Dam-Hieu; Isabelle Quintin-Roué; Jean Sebastien Guillamo; Emmanuelle Lechapt-Zalcman; Jean Louis Kemeny; Pierre Verrelle; Thierry Faillot; Claude Gaultier; Marie Christine Tortel; Christo Christov; Caroline Le Guerinel; Marie Hélène Aubriot-Lorton; Francois Ghiringhelli; François Berger; Catherine Lacroix; Fabrice Parker; François Dubois; Claude Alain Maurage; Edouard Marcel Gueye; Francois Labrousse; Anne Jouvet; Luc Bauchet; Valérie Rigau; Patrick Beauchesne; Jean Michel Vignaud; Mario Campone; Delphine Loussouarn; Denys Fontaine; Fanny Vandenbos; Chantal Campello; Pascal Roger; Melanie Fesneau; Anne Heitzmann; Jean Yves Delattre; Selma Elouadhani; Karima Mokhtari; Marc Polivka; Damien Ricard; Pierre Marie Levillain; Michel Wager; Philippe Colin; Marie Danièle Diebold; Dan Chiforeanu; Elodie Vauleon; Olivier Langlois; Annie Laquerriere; Marie Janette Motsuo Fotso; Michel Peoc'H; Marie Andraud; Servane Mouton; Marie Pierre Chenard; Georges Noel; Nicolas Desse; Raoulin Soulard; Alexandra Amiel-Benouaich; Emmanuelle Uro-Coste; Frederic Dhermain

doi:10.1093/neuonc/not235

Contrast enhancement in 1p/19q-codeleted anaplastic oligodendrogliomas is associated with 9p loss, genomic instability, and angiogenic gene expression

German Reyes-Botero, Caroline Dehais, Ahmed Idbaih, Nadine Martin-Duverneuil, Marion Lahutte, Catherine Carpentier, Eric Letouzé, Olivier Chinot, Hugues Loiseau, Jerome Honnorat, Carole Ramirez, Elisabeth Moyal, Dominique Figarella-Branger, François Ducray, Christine Desenclos, Henri Sevestre, Philippe Menei, Sophie Michalak, Edmond Al Nader, Joel GodardGabriel Viennet, Antoine Carpentier, Sandrine Eimer, Phong Dam-Hieu, Isabelle Quintin-Roué, Jean Sebastien Guillamo, Emmanuelle Lechapt-Zalcman, Jean Louis Kemeny, Pierre Verrelle, Thierry Faillot, Claude Gaultier, Marie Christine Tortel, Christo Christov, Caroline Le Guerinel, Marie Hélène Aubriot-Lorton, Francois Ghiringhelli, François Berger, Catherine Lacroix, Fabrice Parker, François Dubois, Claude Alain Maurage, Edouard Marcel Gueye, Francois Labrousse, Anne Jouvet, Luc Bauchet, Valérie Rigau, Patrick Beauchesne, Jean Michel Vignaud, Mario Campone, Delphine Loussouarn, Denys Fontaine, Fanny Vandenbos, Chantal Campello, Pascal Roger, Melanie Fesneau, Anne Heitzmann, Jean Yves Delattre, Selma Elouadhani, Karima Mokhtari, Marc Polivka, Damien Ricard, Pierre Marie Levillain, Michel Wager, Philippe Colin, Marie Danièle Diebold, Dan Chiforeanu, Elodie Vauleon, Olivier Langlois, Annie Laquerriere, Marie Janette Motsuo Fotso, Michel Peoc'H, Marie Andraud, Servane Mouton, Marie Pierre Chenard, Georges Noel, Nicolas Desse, Raoulin Soulard, Alexandra Amiel-Benouaich, Emmanuelle Uro-Coste, Frederic Dhermain

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

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Résumé

BackgroundThe aim of this study was to correlate MRI features and molecular characteristics in anaplastic oligodendrogliomas (AOs).MethodsThe MRI characteristics of 50 AO patients enrolled in the French national network for high-grade oligodendroglial tumors were analyzed. The genomic profiles and IDH mutational statuses were assessed using high-resolution single-nucleotide polymorphism arrays and direct sequencing, respectively. The gene expression profiles of 25 1p/19q-codeleted AOs were studied on Affymetrix expression arrays.ResultsMost of the cases were frontal lobe contrast-enhanced tumors (52%), but the radiological presentations of these cases were heterogeneous, ranging from low-grade glioma-like aspects (26%) to glioblastoma-like aspects (22%). The 1p/19q codeletion (n = 39) was associated with locations in the frontal lobe (P =. 001), with heterogeneous intratumoral signal intensities (P =. 003) and with no or nonmeasurable contrast enhancements (P =. 01). The IDH wild-type AOs (n = 7) more frequently displayed ringlike contrast enhancements (P =. 03) and were more frequently located outside of the frontal lobe (P =. 01). However, no specific imaging pattern could be identified for the 1p/19q-codeleted AO or the IDH-mutated AO. Within the 1p/19q-codeleted AO, the contrast enhancement was associated with larger tumor volumes (P =. 001), chromosome 9p loss and CDKN2A loss (P =. 006), genomic instability (P =. 03), and angiogenesis-related gene expression (P <. 001), particularly for vascular endothelial growth factor A and angiopoietin 2.ConclusionIn AOs, the 1p/19q codeletion and the IDH mutation are associated with preferential (but not with specific) imaging characteristics. Within 1p/19q-codeleted AO, imaging heterogeneity is related to additional molecular alterations, especially chromosome 9p loss, which is associated with contrast enhancement and larger tumor volume.

langue originale	Anglais
Pages (de - à)	662-670
Nombre de pages	9
journal	Neuro-Oncology
Volume	16
Numéro de publication	5
Les DOIs	https://doi.org/10.1093/neuonc/not235
état	Publié - 1 janv. 2014

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10.1093/neuonc/not235

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Reyes-Botero, G., Dehais, C., Idbaih, A., Martin-Duverneuil, N., Lahutte, M., Carpentier, C., Letouzé, E., Chinot, O., Loiseau, H., Honnorat, J., Ramirez, C., Moyal, E., Figarella-Branger, D., Ducray, F., Desenclos, C., Sevestre, H., Menei, P., Michalak, S., Al Nader, E., ... Dhermain, F. (2014). Contrast enhancement in 1p/19q-codeleted anaplastic oligodendrogliomas is associated with 9p loss, genomic instability, and angiogenic gene expression. Neuro-Oncology, 16(5), 662-670. https://doi.org/10.1093/neuonc/not235

@article{33ce1b1528a3413fa94c28ca0db9941a,

title = "Contrast enhancement in 1p/19q-codeleted anaplastic oligodendrogliomas is associated with 9p loss, genomic instability, and angiogenic gene expression",

abstract = "BackgroundThe aim of this study was to correlate MRI features and molecular characteristics in anaplastic oligodendrogliomas (AOs).MethodsThe MRI characteristics of 50 AO patients enrolled in the French national network for high-grade oligodendroglial tumors were analyzed. The genomic profiles and IDH mutational statuses were assessed using high-resolution single-nucleotide polymorphism arrays and direct sequencing, respectively. The gene expression profiles of 25 1p/19q-codeleted AOs were studied on Affymetrix expression arrays.ResultsMost of the cases were frontal lobe contrast-enhanced tumors (52%), but the radiological presentations of these cases were heterogeneous, ranging from low-grade glioma-like aspects (26%) to glioblastoma-like aspects (22%). The 1p/19q codeletion (n = 39) was associated with locations in the frontal lobe (P =. 001), with heterogeneous intratumoral signal intensities (P =. 003) and with no or nonmeasurable contrast enhancements (P =. 01). The IDH wild-type AOs (n = 7) more frequently displayed ringlike contrast enhancements (P =. 03) and were more frequently located outside of the frontal lobe (P =. 01). However, no specific imaging pattern could be identified for the 1p/19q-codeleted AO or the IDH-mutated AO. Within the 1p/19q-codeleted AO, the contrast enhancement was associated with larger tumor volumes (P =. 001), chromosome 9p loss and CDKN2A loss (P =. 006), genomic instability (P =. 03), and angiogenesis-related gene expression (P <. 001), particularly for vascular endothelial growth factor A and angiopoietin 2.ConclusionIn AOs, the 1p/19q codeletion and the IDH mutation are associated with preferential (but not with specific) imaging characteristics. Within 1p/19q-codeleted AO, imaging heterogeneity is related to additional molecular alterations, especially chromosome 9p loss, which is associated with contrast enhancement and larger tumor volume.",

keywords = "1p19q co-deletion, Anaplastic oligodendroglioma, IDH mutation, Magnetic resonance imaging, SNP array",

author = "German Reyes-Botero and Caroline Dehais and Ahmed Idbaih and Nadine Martin-Duverneuil and Marion Lahutte and Catherine Carpentier and Eric Letouz{\'e} and Olivier Chinot and Hugues Loiseau and Jerome Honnorat and Carole Ramirez and Elisabeth Moyal and Dominique Figarella-Branger and Fran{\c c}ois Ducray and Christine Desenclos and Henri Sevestre and Philippe Menei and Sophie Michalak and {Al Nader}, Edmond and Joel Godard and Gabriel Viennet and Antoine Carpentier and Sandrine Eimer and Phong Dam-Hieu and Isabelle Quintin-Rou{\'e} and Guillamo, {Jean Sebastien} and Emmanuelle Lechapt-Zalcman and Kemeny, {Jean Louis} and Pierre Verrelle and Thierry Faillot and Claude Gaultier and Tortel, {Marie Christine} and Christo Christov and {Le Guerinel}, Caroline and Aubriot-Lorton, {Marie H{\'e}l{\`e}ne} and Francois Ghiringhelli and Fran{\c c}ois Berger and Catherine Lacroix and Fabrice Parker and Fran{\c c}ois Dubois and Maurage, {Claude Alain} and Gueye, {Edouard Marcel} and Francois Labrousse and Anne Jouvet and Luc Bauchet and Val{\'e}rie Rigau and Patrick Beauchesne and Vignaud, {Jean Michel} and Mario Campone and Delphine Loussouarn and Denys Fontaine and Fanny Vandenbos and Chantal Campello and Pascal Roger and Melanie Fesneau and Anne Heitzmann and Delattre, {Jean Yves} and Selma Elouadhani and Karima Mokhtari and Marc Polivka and Damien Ricard and Levillain, {Pierre Marie} and Michel Wager and Philippe Colin and Diebold, {Marie Dani{\`e}le} and Dan Chiforeanu and Elodie Vauleon and Olivier Langlois and Annie Laquerriere and {Motsuo Fotso}, {Marie Janette} and Michel Peoc'H and Marie Andraud and Servane Mouton and Chenard, {Marie Pierre} and Georges Noel and Nicolas Desse and Raoulin Soulard and Alexandra Amiel-Benouaich and Emmanuelle Uro-Coste and Frederic Dhermain",

year = "2014",

month = jan,

day = "1",

doi = "10.1093/neuonc/not235",

language = "English",

volume = "16",

pages = "662--670",

journal = "Neuro-Oncology",

issn = "1522-8517",

number = "5",

}

Reyes-Botero, G, Dehais, C, Idbaih, A, Martin-Duverneuil, N, Lahutte, M, Carpentier, C, Letouzé, E, Chinot, O, Loiseau, H, Honnorat, J, Ramirez, C, Moyal, E, Figarella-Branger, D, Ducray, F, Desenclos, C, Sevestre, H, Menei, P, Michalak, S, Al Nader, E, Godard, J, Viennet, G, Carpentier, A, Eimer, S, Dam-Hieu, P, Quintin-Roué, I, Guillamo, JS, Lechapt-Zalcman, E, Kemeny, JL, Verrelle, P, Faillot, T, Gaultier, C, Tortel, MC, Christov, C, Le Guerinel, C, Aubriot-Lorton, MH, Ghiringhelli, F, Berger, F, Lacroix, C, Parker, F, Dubois, F, Maurage, CA, Gueye, EM, Labrousse, F, Jouvet, A, Bauchet, L, Rigau, V, Beauchesne, P, Vignaud, JM, Campone, M, Loussouarn, D, Fontaine, D, Vandenbos, F, Campello, C, Roger, P, Fesneau, M, Heitzmann, A, Delattre, JY, Elouadhani, S, Mokhtari, K, Polivka, M, Ricard, D, Levillain, PM, Wager, M, Colin, P, Diebold, MD, Chiforeanu, D, Vauleon, E, Langlois, O, Laquerriere, A, Motsuo Fotso, MJ, Peoc'H, M, Andraud, M, Mouton, S, Chenard, MP, Noel, G, Desse, N, Soulard, R, Amiel-Benouaich, A, Uro-Coste, E & Dhermain, F 2014, 'Contrast enhancement in 1p/19q-codeleted anaplastic oligodendrogliomas is associated with 9p loss, genomic instability, and angiogenic gene expression', Neuro-Oncology, VOL. 16, Numéro 5, p. 662-670. https://doi.org/10.1093/neuonc/not235

TY - JOUR

T1 - Contrast enhancement in 1p/19q-codeleted anaplastic oligodendrogliomas is associated with 9p loss, genomic instability, and angiogenic gene expression

AU - Reyes-Botero, German

AU - Dehais, Caroline

AU - Idbaih, Ahmed

AU - Martin-Duverneuil, Nadine

AU - Lahutte, Marion

AU - Carpentier, Catherine

AU - Letouzé, Eric

AU - Chinot, Olivier

AU - Loiseau, Hugues

AU - Honnorat, Jerome

AU - Ramirez, Carole

AU - Moyal, Elisabeth

AU - Figarella-Branger, Dominique

AU - Ducray, François

AU - Desenclos, Christine

AU - Sevestre, Henri

AU - Menei, Philippe

AU - Michalak, Sophie

AU - Al Nader, Edmond

AU - Godard, Joel

AU - Viennet, Gabriel

AU - Carpentier, Antoine

AU - Eimer, Sandrine

AU - Dam-Hieu, Phong

AU - Quintin-Roué, Isabelle

AU - Guillamo, Jean Sebastien

AU - Lechapt-Zalcman, Emmanuelle

AU - Kemeny, Jean Louis

AU - Verrelle, Pierre

AU - Faillot, Thierry

AU - Gaultier, Claude

AU - Tortel, Marie Christine

AU - Christov, Christo

AU - Le Guerinel, Caroline

AU - Aubriot-Lorton, Marie Hélène

AU - Ghiringhelli, Francois

AU - Berger, François

AU - Lacroix, Catherine

AU - Parker, Fabrice

AU - Dubois, François

AU - Maurage, Claude Alain

AU - Gueye, Edouard Marcel

AU - Labrousse, Francois

AU - Jouvet, Anne

AU - Bauchet, Luc

AU - Rigau, Valérie

AU - Beauchesne, Patrick

AU - Vignaud, Jean Michel

AU - Campone, Mario

AU - Loussouarn, Delphine

AU - Fontaine, Denys

AU - Vandenbos, Fanny

AU - Campello, Chantal

AU - Roger, Pascal

AU - Fesneau, Melanie

AU - Heitzmann, Anne

AU - Delattre, Jean Yves

AU - Elouadhani, Selma

AU - Mokhtari, Karima

AU - Polivka, Marc

AU - Ricard, Damien

AU - Levillain, Pierre Marie

AU - Wager, Michel

AU - Colin, Philippe

AU - Diebold, Marie Danièle

AU - Chiforeanu, Dan

AU - Vauleon, Elodie

AU - Langlois, Olivier

AU - Laquerriere, Annie

AU - Motsuo Fotso, Marie Janette

AU - Peoc'H, Michel

AU - Andraud, Marie

AU - Mouton, Servane

AU - Chenard, Marie Pierre

AU - Noel, Georges

AU - Desse, Nicolas

AU - Soulard, Raoulin

AU - Amiel-Benouaich, Alexandra

AU - Uro-Coste, Emmanuelle

AU - Dhermain, Frederic

PY - 2014/1/1

Y1 - 2014/1/1

N2 - BackgroundThe aim of this study was to correlate MRI features and molecular characteristics in anaplastic oligodendrogliomas (AOs).MethodsThe MRI characteristics of 50 AO patients enrolled in the French national network for high-grade oligodendroglial tumors were analyzed. The genomic profiles and IDH mutational statuses were assessed using high-resolution single-nucleotide polymorphism arrays and direct sequencing, respectively. The gene expression profiles of 25 1p/19q-codeleted AOs were studied on Affymetrix expression arrays.ResultsMost of the cases were frontal lobe contrast-enhanced tumors (52%), but the radiological presentations of these cases were heterogeneous, ranging from low-grade glioma-like aspects (26%) to glioblastoma-like aspects (22%). The 1p/19q codeletion (n = 39) was associated with locations in the frontal lobe (P =. 001), with heterogeneous intratumoral signal intensities (P =. 003) and with no or nonmeasurable contrast enhancements (P =. 01). The IDH wild-type AOs (n = 7) more frequently displayed ringlike contrast enhancements (P =. 03) and were more frequently located outside of the frontal lobe (P =. 01). However, no specific imaging pattern could be identified for the 1p/19q-codeleted AO or the IDH-mutated AO. Within the 1p/19q-codeleted AO, the contrast enhancement was associated with larger tumor volumes (P =. 001), chromosome 9p loss and CDKN2A loss (P =. 006), genomic instability (P =. 03), and angiogenesis-related gene expression (P <. 001), particularly for vascular endothelial growth factor A and angiopoietin 2.ConclusionIn AOs, the 1p/19q codeletion and the IDH mutation are associated with preferential (but not with specific) imaging characteristics. Within 1p/19q-codeleted AO, imaging heterogeneity is related to additional molecular alterations, especially chromosome 9p loss, which is associated with contrast enhancement and larger tumor volume.

AB - BackgroundThe aim of this study was to correlate MRI features and molecular characteristics in anaplastic oligodendrogliomas (AOs).MethodsThe MRI characteristics of 50 AO patients enrolled in the French national network for high-grade oligodendroglial tumors were analyzed. The genomic profiles and IDH mutational statuses were assessed using high-resolution single-nucleotide polymorphism arrays and direct sequencing, respectively. The gene expression profiles of 25 1p/19q-codeleted AOs were studied on Affymetrix expression arrays.ResultsMost of the cases were frontal lobe contrast-enhanced tumors (52%), but the radiological presentations of these cases were heterogeneous, ranging from low-grade glioma-like aspects (26%) to glioblastoma-like aspects (22%). The 1p/19q codeletion (n = 39) was associated with locations in the frontal lobe (P =. 001), with heterogeneous intratumoral signal intensities (P =. 003) and with no or nonmeasurable contrast enhancements (P =. 01). The IDH wild-type AOs (n = 7) more frequently displayed ringlike contrast enhancements (P =. 03) and were more frequently located outside of the frontal lobe (P =. 01). However, no specific imaging pattern could be identified for the 1p/19q-codeleted AO or the IDH-mutated AO. Within the 1p/19q-codeleted AO, the contrast enhancement was associated with larger tumor volumes (P =. 001), chromosome 9p loss and CDKN2A loss (P =. 006), genomic instability (P =. 03), and angiogenesis-related gene expression (P <. 001), particularly for vascular endothelial growth factor A and angiopoietin 2.ConclusionIn AOs, the 1p/19q codeletion and the IDH mutation are associated with preferential (but not with specific) imaging characteristics. Within 1p/19q-codeleted AO, imaging heterogeneity is related to additional molecular alterations, especially chromosome 9p loss, which is associated with contrast enhancement and larger tumor volume.

KW - 1p19q co-deletion

KW - Anaplastic oligodendroglioma

KW - IDH mutation

KW - Magnetic resonance imaging

KW - SNP array

UR - http://www.scopus.com/inward/record.url?scp=84899457632&partnerID=8YFLogxK

U2 - 10.1093/neuonc/not235

DO - 10.1093/neuonc/not235

M3 - Article

C2 - 24353325

AN - SCOPUS:84899457632

SN - 1522-8517

VL - 16

SP - 662

EP - 670

JO - Neuro-Oncology

JF - Neuro-Oncology

IS - 5

ER -