TY - JOUR
T1 - Cutting edge
T2 - JAM-C controls homeostatic chemokine secretion in lymph node fibroblastic reticular cells expressing thrombomodulin
AU - Frontera, Vincent
AU - Arcangeli, Marie Laure
AU - Zimmerli, Claudia
AU - Bardin, Florence
AU - Obrados, Elodie
AU - Audebert, Stéphane
AU - Bajenoff, Marc
AU - Borg, Jean Paul
AU - Aurrand-Lions, Michel
PY - 2011/7/15
Y1 - 2011/7/15
N2 - The development and maintenance of secondary lymphoid organs, such as lymph nodes, occur in a highly coordinated manner involving lymphoid chemokine production by stromal cells. Although developmental pathways inducing lymphoid chemokine production during organogenesis are known, signals maintaining cytokine production in adults are still elusive. In this study, we show that thrombomodulin and platelet-derived growth factor receptor a identify a population of fibroblastic reticular cells in which chemokine secretion is controlled by JAM-C. We demonstrate that Jam-C - deficient mice and mice treated with Ab against JAM-C present significant decreases in stromal cell-derived factor 1a (CXCL12), CCL21, and CCL19 intranodal content. This effect is correlated with reduced naive T cell egress from lymph nodes of anti - JAM-C - treated mice.
AB - The development and maintenance of secondary lymphoid organs, such as lymph nodes, occur in a highly coordinated manner involving lymphoid chemokine production by stromal cells. Although developmental pathways inducing lymphoid chemokine production during organogenesis are known, signals maintaining cytokine production in adults are still elusive. In this study, we show that thrombomodulin and platelet-derived growth factor receptor a identify a population of fibroblastic reticular cells in which chemokine secretion is controlled by JAM-C. We demonstrate that Jam-C - deficient mice and mice treated with Ab against JAM-C present significant decreases in stromal cell-derived factor 1a (CXCL12), CCL21, and CCL19 intranodal content. This effect is correlated with reduced naive T cell egress from lymph nodes of anti - JAM-C - treated mice.
UR - http://www.scopus.com/inward/record.url?scp=79960484211&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.1003441
DO - 10.4049/jimmunol.1003441
M3 - Article
C2 - 21685324
AN - SCOPUS:79960484211
SN - 0022-1767
VL - 187
SP - 603
EP - 607
JO - Journal of Immunology
JF - Journal of Immunology
IS - 2
ER -