Dactinomycin-induced, severe lichenoid eruption in a child

V. Ridola, E. Mahé, O. Fawaz, L. Galmiche, C. Patte, J. Grill

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    Résumé

    There is little information in the medical literature about skin rashes associated with dactinomycin in the absence of radiotherapy. We report a 12-month-old male child who developed a severe cutaneous reaction that consisted of a widespread pruritic papular eruption associated with fever and a poor general state after dactinomycin administration. Skin biopsy specimen findings confirmed the diagnosis of lichenoid eruption. The rash improved with topical steroid treatment and completely resolved within 1 month with persistence of a residual mild hyperpigmentation. Dactinomycin administration was discontinued for the remaining cycles of chemotherapy.

    langue originaleAnglais
    Pages (de - à)503-506
    Nombre de pages4
    journalPediatric Dermatology
    Volume23
    Numéro de publication5
    Les DOIs
    étatPublié - 1 sept. 2006

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