Defective Immunity against SARS-CoV-2 Omicron Variants despite Full Vaccination in Hematologic Malignancies

Laurence Zitvogel, Lisa Derosa, Guido Kroemer

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    Résumé

    In patients with multiple myeloma, completion of mRNA-based vaccination schemes failed to yield detectable SARS-CoV-2 Omicron-neutralizing antibodies and S1-RBD–specific CD8+ T cells in approximately 60% and 80% of the cases, respectively. Patients who develop breakthrough infections exhibited very low levels of live-virus neutralizing antibodies and the absence of follicular T helper cells.

    langue originaleAnglais
    Pages (de - à)172-175
    Nombre de pages4
    journalBlood Cancer Discovery
    Volume4
    Numéro de publication3
    Les DOIs
    étatPublié - 1 mai 2023

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