Defective Immunity against SARS-CoV-2 Omicron Variants despite Full Vaccination in Hematologic Malignancies

Laurence Zitvogel; Lisa Derosa; Guido Kroemer

doi:10.1158/2643-3230.BCD-22-0213

Defective Immunity against SARS-CoV-2 Omicron Variants despite Full Vaccination in Hematologic Malignancies

Laurence Zitvogel, Lisa Derosa, Guido Kroemer

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

Résumé

In patients with multiple myeloma, completion of mRNA-based vaccination schemes failed to yield detectable SARS-CoV-2 Omicron-neutralizing antibodies and S1-RBD–specific CD8⁺ T cells in approximately 60% and 80% of the cases, respectively. Patients who develop breakthrough infections exhibited very low levels of live-virus neutralizing antibodies and the absence of follicular T helper cells.

langue originale	Anglais
Pages (de - à)	172-175
Nombre de pages	4
journal	Blood Cancer Discovery
Volume	4
Numéro de publication	3
Les DOIs	https://doi.org/10.1158/2643-3230.BCD-22-0213
état	Publié - 1 mai 2023
Modification externe	Oui

Accès au document

10.1158/2643-3230.BCD-22-0213

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title = "Defective Immunity against SARS-CoV-2 Omicron Variants despite Full Vaccination in Hematologic Malignancies",

abstract = "In patients with multiple myeloma, completion of mRNA-based vaccination schemes failed to yield detectable SARS-CoV-2 Omicron-neutralizing antibodies and S1-RBD–specific CD8+ T cells in approximately 60% and 80% of the cases, respectively. Patients who develop breakthrough infections exhibited very low levels of live-virus neutralizing antibodies and the absence of follicular T helper cells.",

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