Defining myeloid-derived suppressor cells

Leila Akkari; Ido Amit; Vincenzo Bronte; Zvi G. Fridlender; Dmitry I. Gabrilovich; Florent Ginhoux; Catherine C. Hedrick; Suzanne Ostrand-Rosenberg

doi:10.1038/s41577-024-01062-0

Defining myeloid-derived suppressor cells

Leila Akkari, Ido Amit, Vincenzo Bronte, Zvi G. Fridlender, Dmitry I. Gabrilovich, Florent Ginhoux, Catherine C. Hedrick, Suzanne Ostrand-Rosenberg

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

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Résumé

Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However, there is still much controversy regarding their identity, ontogeny and functions that must be resolved to fulfill their therapeutic potential. In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research.

langue originale	Anglais
Pages (de - à)	850-857
Nombre de pages	8
journal	Nature Reviews Immunology
Volume	24
Numéro de publication	12
Les DOIs	https://doi.org/10.1038/s41577-024-01062-0
état	Publié - 1 déc. 2024

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10.1038/s41577-024-01062-0

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title = "Defining myeloid-derived suppressor cells",

abstract = "Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However, there is still much controversy regarding their identity, ontogeny and functions that must be resolved to fulfill their therapeutic potential. In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research.",

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AU - Amit, Ido

AU - Bronte, Vincenzo

AU - Fridlender, Zvi G.

AU - Gabrilovich, Dmitry I.

AU - Ginhoux, Florent

AU - Hedrick, Catherine C.

AU - Ostrand-Rosenberg, Suzanne

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AB - Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However, there is still much controversy regarding their identity, ontogeny and functions that must be resolved to fulfill their therapeutic potential. In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research.

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