Denosumab Toxicity When Combined With Anti-angiogenic Therapies on Patients With Metastatic Renal Cell Carcinoma: A GETUG Study

Aline Guillot; Charlotte Joly; Philippe Barthélémy; Emeline Meriaux; Sylvie Negrier; Damien Pouessel; Christine Chevreau; Hakim Mahammedi; Nadine Houede; Guilhem Roubaud; Gwenaelle Gravis; Sophie Tartas; Laurence Albiges; Cécile Vassal; Mathieu Oriol; Fabien Tinquaut; Sophie Espenel; Wafa Bouleftour; Stéphane Culine; Karim Fizazi

doi:10.1016/j.clgc.2018.08.006

Denosumab Toxicity When Combined With Anti-angiogenic Therapies on Patients With Metastatic Renal Cell Carcinoma: A GETUG Study

Aline Guillot, Charlotte Joly, Philippe Barthélémy, Emeline Meriaux, Sylvie Negrier, Damien Pouessel, Christine Chevreau, Hakim Mahammedi, Nadine Houede, Guilhem Roubaud, Gwenaelle Gravis, Sophie Tartas, Laurence Albiges, Cécile Vassal, Mathieu Oriol, Fabien Tinquaut, Sophie Espenel, Wafa Bouleftour, Stéphane Culine, Karim Fizazi

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Résumé

The aim of this multicenter retrospective study is to analyze the toxicity profile (mainly osteonecrosis of the jaw) of patients with metastatic renal cell carcinoma treated with denosumab and anti-angiogenic combination. Of 41 patients enrolled in this study, 7 patients developed osteonecrosis of the jaw. This toxicity signal should warn physicians about this combination in the population with metastatic renal cell carcinoma.

langue originale	Anglais
Pages (de - à)	e38-e43
journal	Clinical Genitourinary Cancer
Volume	17
Numéro de publication	1
Les DOIs	https://doi.org/10.1016/j.clgc.2018.08.006
état	Publié - 1 févr. 2019

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10.1016/j.clgc.2018.08.006

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Guillot, A., Joly, C., Barthélémy, P., Meriaux, E., Negrier, S., Pouessel, D., Chevreau, C., Mahammedi, H., Houede, N., Roubaud, G., Gravis, G., Tartas, S., Albiges, L., Vassal, C., Oriol, M., Tinquaut, F., Espenel, S., Bouleftour, W., Culine, S., & Fizazi, K. (2019). Denosumab Toxicity When Combined With Anti-angiogenic Therapies on Patients With Metastatic Renal Cell Carcinoma: A GETUG Study. Clinical Genitourinary Cancer, 17(1), e38-e43. https://doi.org/10.1016/j.clgc.2018.08.006

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title = "Denosumab Toxicity When Combined With Anti-angiogenic Therapies on Patients With Metastatic Renal Cell Carcinoma: A GETUG Study",

abstract = "The aim of this multicenter retrospective study is to analyze the toxicity profile (mainly osteonecrosis of the jaw) of patients with metastatic renal cell carcinoma treated with denosumab and anti-angiogenic combination. Of 41 patients enrolled in this study, 7 patients developed osteonecrosis of the jaw. This toxicity signal should warn physicians about this combination in the population with metastatic renal cell carcinoma.",

keywords = "Anti-angiogenic therapies, Bone metastasis, Desosumab, Metastatic renal cell carcinoma, Osteonecrosis of the jaw",

author = "Aline Guillot and Charlotte Joly and Philippe Barth{\'e}l{\'e}my and Emeline Meriaux and Sylvie Negrier and Damien Pouessel and Christine Chevreau and Hakim Mahammedi and Nadine Houede and Guilhem Roubaud and Gwenaelle Gravis and Sophie Tartas and Laurence Albiges and C{\'e}cile Vassal and Mathieu Oriol and Fabien Tinquaut and Sophie Espenel and Wafa Bouleftour and St{\'e}phane Culine and Karim Fizazi",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2019",

month = feb,

day = "1",

doi = "10.1016/j.clgc.2018.08.006",

language = "English",

volume = "17",

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journal = "Clinical Genitourinary Cancer",

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Guillot, A, Joly, C, Barthélémy, P, Meriaux, E, Negrier, S, Pouessel, D, Chevreau, C, Mahammedi, H, Houede, N, Roubaud, G, Gravis, G, Tartas, S, Albiges, L, Vassal, C, Oriol, M, Tinquaut, F, Espenel, S, Bouleftour, W, Culine, S & Fizazi, K 2019, 'Denosumab Toxicity When Combined With Anti-angiogenic Therapies on Patients With Metastatic Renal Cell Carcinoma: A GETUG Study', Clinical Genitourinary Cancer, VOL. 17, Numéro 1, p. e38-e43. https://doi.org/10.1016/j.clgc.2018.08.006

TY - JOUR

T1 - Denosumab Toxicity When Combined With Anti-angiogenic Therapies on Patients With Metastatic Renal Cell Carcinoma

T2 - A GETUG Study

AU - Guillot, Aline

AU - Joly, Charlotte

AU - Barthélémy, Philippe

AU - Meriaux, Emeline

AU - Negrier, Sylvie

AU - Pouessel, Damien

AU - Chevreau, Christine

AU - Mahammedi, Hakim

AU - Houede, Nadine

AU - Roubaud, Guilhem

AU - Gravis, Gwenaelle

AU - Tartas, Sophie

AU - Albiges, Laurence

AU - Vassal, Cécile

AU - Oriol, Mathieu

AU - Tinquaut, Fabien

AU - Espenel, Sophie

AU - Bouleftour, Wafa

AU - Culine, Stéphane

AU - Fizazi, Karim

PY - 2019/2/1

Y1 - 2019/2/1

N2 - The aim of this multicenter retrospective study is to analyze the toxicity profile (mainly osteonecrosis of the jaw) of patients with metastatic renal cell carcinoma treated with denosumab and anti-angiogenic combination. Of 41 patients enrolled in this study, 7 patients developed osteonecrosis of the jaw. This toxicity signal should warn physicians about this combination in the population with metastatic renal cell carcinoma.

AB - The aim of this multicenter retrospective study is to analyze the toxicity profile (mainly osteonecrosis of the jaw) of patients with metastatic renal cell carcinoma treated with denosumab and anti-angiogenic combination. Of 41 patients enrolled in this study, 7 patients developed osteonecrosis of the jaw. This toxicity signal should warn physicians about this combination in the population with metastatic renal cell carcinoma.

KW - Anti-angiogenic therapies

KW - Bone metastasis

KW - Desosumab

KW - Metastatic renal cell carcinoma

KW - Osteonecrosis of the jaw

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U2 - 10.1016/j.clgc.2018.08.006

DO - 10.1016/j.clgc.2018.08.006

M3 - Article

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AN - SCOPUS:85054073631

SN - 1558-7673

VL - 17

SP - e38-e43

JO - Clinical Genitourinary Cancer

JF - Clinical Genitourinary Cancer

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