Résumé
Endonuclease G is a mitochondrio-nuclear located nuclease with dual - vital and lethal - functions. Besides its role in apoptosis execution, we have recently shown that depletion of endonuclease G leads to necrotic cell death in yeast. Here, we present further mechanistic elucidation of endonuclease G's vital functions. The deletion of the yeast Endonuclease G gene causes the complete elimination of tetraploid cells during exponential growth. Consistently, conditional knockdown of mammalian endonuclease G selectively kills tetraploid but not diploid clones of the human HCT116 colon carcinoma cell line. We conclude that endonuclease G is important for the viability of polyploid mammalian and yeast cells.
langue originale | Anglais |
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Pages (de - à) | 1072-1076 |
Nombre de pages | 5 |
journal | Cell Cycle |
Volume | 6 |
Numéro de publication | 9 |
Les DOIs | |
état | Publié - 1 mai 2007 |