TY - JOUR
T1 - Deregulated expression of the TAL1 gene by t(1;5)(p32;q31) in patient with T-cell acute lymphoblastic leukemia
AU - François, Sylvie
AU - Delabesse, Eric
AU - Baranger, Laurence
AU - Dautel, Marie
AU - Foussard, Charles
AU - Boasson, Marc
AU - Blanchet, Odile
AU - Bernard, Olivier
AU - Macintyre, Elizabeth A.
AU - Ifrah, Norbert
PY - 1998/1/1
Y1 - 1998/1/1
N2 - TAL1 gene deregulation is frequent in T-cell acute lymphoblastic leukemia (T-ALL) and can result from translocations involving 1p32 or, more frequently, from a cytogenetically undetectable interstitial deletion of chromosome 1. This study presents a case of T-ALL with a t(1;5) (p32;q31) involving TAL1, in which the breakpoint occurs approximately 10 kbp 5' to the gene and leads to transcriptional activation and synthesis of a TALl protein, and extends the spectrum of recognized TAL1 gene translocations associated with T-ALL.
AB - TAL1 gene deregulation is frequent in T-cell acute lymphoblastic leukemia (T-ALL) and can result from translocations involving 1p32 or, more frequently, from a cytogenetically undetectable interstitial deletion of chromosome 1. This study presents a case of T-ALL with a t(1;5) (p32;q31) involving TAL1, in which the breakpoint occurs approximately 10 kbp 5' to the gene and leads to transcriptional activation and synthesis of a TALl protein, and extends the spectrum of recognized TAL1 gene translocations associated with T-ALL.
UR - http://www.scopus.com/inward/record.url?scp=0344333431&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1098-2264(199809)23:1<36::AID-GCC6>3.0.CO;2-7
DO - 10.1002/(SICI)1098-2264(199809)23:1<36::AID-GCC6>3.0.CO;2-7
M3 - Article
C2 - 9713995
AN - SCOPUS:0344333431
SN - 1045-2257
VL - 23
SP - 36
EP - 43
JO - Genes Chromosomes and Cancer
JF - Genes Chromosomes and Cancer
IS - 1
ER -