Dietary advanced glycation end-products and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study

Elom K. Aglago; Ana Lucia Mayén; Viktoria Knaze; Heinz Freisling; Veronika Fedirko; David J. Hughes; Li Jiao; Anne Kirstine Eriksen; Anne Tjønneland; Marie Christine Boutron-Ruault; Joseph A. Rothwell; Gianluca Severi; Rudolf Kaaks; Verena Katzke; Matthias B. Schulze; Anna Birukov; Domenico Palli; Sabina Sieri; Maria Santucci De Magistris; Rosario Tumino; Fulvio Ricceri; Bas Bueno-De-Mesquita; Jeroen W.G. Derksen; Guri Skeie; Inger Torhild Gram; Torkjel Sandanger; J. Ramón Quirós; Leila Luján-Barroso; Maria Jose Sánchez; Pilar Amiano; María Dolores Chirlaque; Aurelio Barricarte Gurrea; Ingegerd Johansson; Jonas Manjer; Aurora Perez-Cornago; Elisabete Weiderpass; Marc J. Gunter; Alicia K. Heath; Casper G. Schalkwijk; Mazda Jenab

doi:10.3390/nu13093132

Dietary advanced glycation end-products and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study

Elom K. Aglago, Ana Lucia Mayén, Viktoria Knaze, Heinz Freisling, Veronika Fedirko, David J. Hughes, Li Jiao, Anne Kirstine Eriksen, Anne Tjønneland, Marie Christine Boutron-Ruault, Joseph A. Rothwell, Gianluca Severi, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Anna Birukov, Domenico Palli, Sabina Sieri, Maria Santucci De Magistris, Rosario TuminoFulvio Ricceri, Bas Bueno-De-Mesquita, Jeroen W.G. Derksen, Guri Skeie, Inger Torhild Gram, Torkjel Sandanger, J. Ramón Quirós, Leila Luján-Barroso, Maria Jose Sánchez, Pilar Amiano, María Dolores Chirlaque, Aurelio Barricarte Gurrea, Ingegerd Johansson, Jonas Manjer, Aurora Perez-Cornago, Elisabete Weiderpass, Marc J. Gunter, Alicia K. Heath, Casper G. Schalkwijk, Mazda Jenab

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

15 Citations (Scopus)

Résumé

Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: N"-carboxy-methyllysine (CML), N^ԑ-carboxyethyllysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated in 450,111 participants (median follow-up = 13 years, with 6162 CRC cases) by matching to a detailed published European food composition database. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of dAGEs with CRC were computed using multivariable-adjusted Cox regression models. Inverse CRC risk associations were observed for CML (HR comparing extreme quintiles: HR_Q5vs.Q1 = 0.92, 95% CI = 0.85–1.00) and MG-H1 (HR_Q5vs.Q1 = 0.92, 95% CI = 0.85–1.00), but not for CEL (HR_Q5vs.Q1 = 0.97, 95% CI = 0.89–1.05). The associations did not differ by sex or anatomical location of the tumor. Contrary to the initial hypothesis, our findings suggest an inverse association between dAGEs and CRC risk. More research is required to verify these findings and better differentiate the role of dAGEs from that of endogenously produced AGEs and their precursor compounds in CRC development.

langue originale	Anglais
Numéro d'article	3132
journal	Nutrients
Volume	13
Numéro de publication	9
Les DOIs	https://doi.org/10.3390/nu13093132
état	Publié - 1 sept. 2021

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10.3390/nu13093132

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Aglago, E. K., Mayén, A. L., Knaze, V., Freisling, H., Fedirko, V., Hughes, D. J., Jiao, L., Eriksen, A. K., Tjønneland, A., Boutron-Ruault, M. C., Rothwell, J. A., Severi, G., Kaaks, R., Katzke, V., Schulze, M. B., Birukov, A., Palli, D., Sieri, S., De Magistris, M. S., ... Jenab, M. (2021). Dietary advanced glycation end-products and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study. Nutrients, 13(9), Article 3132. https://doi.org/10.3390/nu13093132

@article{76a089a3494b4c718f08f1f4101a06a0,

title = "Dietary advanced glycation end-products and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study",

abstract = "Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: N{"}-carboxy-methyllysine (CML), Nԑ-carboxyethyllysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated in 450,111 participants (median follow-up = 13 years, with 6162 CRC cases) by matching to a detailed published European food composition database. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of dAGEs with CRC were computed using multivariable-adjusted Cox regression models. Inverse CRC risk associations were observed for CML (HR comparing extreme quintiles: HRQ5vs.Q1 = 0.92, 95% CI = 0.85–1.00) and MG-H1 (HRQ5vs.Q1 = 0.92, 95% CI = 0.85–1.00), but not for CEL (HRQ5vs.Q1 = 0.97, 95% CI = 0.89–1.05). The associations did not differ by sex or anatomical location of the tumor. Contrary to the initial hypothesis, our findings suggest an inverse association between dAGEs and CRC risk. More research is required to verify these findings and better differentiate the role of dAGEs from that of endogenously produced AGEs and their precursor compounds in CRC development.",

keywords = "Advanced glycation end-products, Colorectal cancer, Dietary exposure, Dietary glycation compounds",

author = "Aglago, {Elom K.} and May{\'e}n, {Ana Lucia} and Viktoria Knaze and Heinz Freisling and Veronika Fedirko and Hughes, {David J.} and Li Jiao and Eriksen, {Anne Kirstine} and Anne Tj{\o}nneland and Boutron-Ruault, {Marie Christine} and Rothwell, {Joseph A.} and Gianluca Severi and Rudolf Kaaks and Verena Katzke and Schulze, {Matthias B.} and Anna Birukov and Domenico Palli and Sabina Sieri and {De Magistris}, {Maria Santucci} and Rosario Tumino and Fulvio Ricceri and Bas Bueno-De-Mesquita and Derksen, {Jeroen W.G.} and Guri Skeie and Gram, {Inger Torhild} and Torkjel Sandanger and Quir{\'o}s, {J. Ram{\'o}n} and Leila Luj{\'a}n-Barroso and S{\'a}nchez, {Maria Jose} and Pilar Amiano and Chirlaque, {Mar{\'i}a Dolores} and Gurrea, {Aurelio Barricarte} and Ingegerd Johansson and Jonas Manjer and Aurora Perez-Cornago and Elisabete Weiderpass and Gunter, {Marc J.} and Heath, {Alicia K.} and Schalkwijk, {Casper G.} and Mazda Jenab",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = sep,

day = "1",

doi = "10.3390/nu13093132",

language = "English",

volume = "13",

journal = "Nutrients",

issn = "2072-6643",

number = "9",

}

Aglago, EK, Mayén, AL, Knaze, V, Freisling, H, Fedirko, V, Hughes, DJ, Jiao, L, Eriksen, AK, Tjønneland, A, Boutron-Ruault, MC, Rothwell, JA, Severi, G, Kaaks, R, Katzke, V, Schulze, MB, Birukov, A, Palli, D, Sieri, S, De Magistris, MS, Tumino, R, Ricceri, F, Bueno-De-Mesquita, B, Derksen, JWG, Skeie, G, Gram, IT, Sandanger, T, Quirós, JR, Luján-Barroso, L, Sánchez, MJ, Amiano, P, Chirlaque, MD, Gurrea, AB, Johansson, I, Manjer, J, Perez-Cornago, A, Weiderpass, E, Gunter, MJ, Heath, AK, Schalkwijk, CG & Jenab, M 2021, 'Dietary advanced glycation end-products and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study', Nutrients, VOL. 13, Numéro 9, 3132. https://doi.org/10.3390/nu13093132

TY - JOUR

T1 - Dietary advanced glycation end-products and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study

AU - Aglago, Elom K.

AU - Mayén, Ana Lucia

AU - Knaze, Viktoria

AU - Freisling, Heinz

AU - Fedirko, Veronika

AU - Hughes, David J.

AU - Jiao, Li

AU - Eriksen, Anne Kirstine

AU - Tjønneland, Anne

AU - Boutron-Ruault, Marie Christine

AU - Rothwell, Joseph A.

AU - Severi, Gianluca

AU - Kaaks, Rudolf

AU - Katzke, Verena

AU - Schulze, Matthias B.

AU - Birukov, Anna

AU - Palli, Domenico

AU - Sieri, Sabina

AU - De Magistris, Maria Santucci

AU - Tumino, Rosario

AU - Ricceri, Fulvio

AU - Bueno-De-Mesquita, Bas

AU - Derksen, Jeroen W.G.

AU - Skeie, Guri

AU - Gram, Inger Torhild

AU - Sandanger, Torkjel

AU - Quirós, J. Ramón

AU - Luján-Barroso, Leila

AU - Sánchez, Maria Jose

AU - Amiano, Pilar

AU - Chirlaque, María Dolores

AU - Gurrea, Aurelio Barricarte

AU - Johansson, Ingegerd

AU - Manjer, Jonas

AU - Perez-Cornago, Aurora

AU - Weiderpass, Elisabete

AU - Gunter, Marc J.

AU - Heath, Alicia K.

AU - Schalkwijk, Casper G.

AU - Jenab, Mazda

PY - 2021/9/1

Y1 - 2021/9/1

N2 - Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: N"-carboxy-methyllysine (CML), Nԑ-carboxyethyllysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated in 450,111 participants (median follow-up = 13 years, with 6162 CRC cases) by matching to a detailed published European food composition database. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of dAGEs with CRC were computed using multivariable-adjusted Cox regression models. Inverse CRC risk associations were observed for CML (HR comparing extreme quintiles: HRQ5vs.Q1 = 0.92, 95% CI = 0.85–1.00) and MG-H1 (HRQ5vs.Q1 = 0.92, 95% CI = 0.85–1.00), but not for CEL (HRQ5vs.Q1 = 0.97, 95% CI = 0.89–1.05). The associations did not differ by sex or anatomical location of the tumor. Contrary to the initial hypothesis, our findings suggest an inverse association between dAGEs and CRC risk. More research is required to verify these findings and better differentiate the role of dAGEs from that of endogenously produced AGEs and their precursor compounds in CRC development.

AB - Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: N"-carboxy-methyllysine (CML), Nԑ-carboxyethyllysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated in 450,111 participants (median follow-up = 13 years, with 6162 CRC cases) by matching to a detailed published European food composition database. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of dAGEs with CRC were computed using multivariable-adjusted Cox regression models. Inverse CRC risk associations were observed for CML (HR comparing extreme quintiles: HRQ5vs.Q1 = 0.92, 95% CI = 0.85–1.00) and MG-H1 (HRQ5vs.Q1 = 0.92, 95% CI = 0.85–1.00), but not for CEL (HRQ5vs.Q1 = 0.97, 95% CI = 0.89–1.05). The associations did not differ by sex or anatomical location of the tumor. Contrary to the initial hypothesis, our findings suggest an inverse association between dAGEs and CRC risk. More research is required to verify these findings and better differentiate the role of dAGEs from that of endogenously produced AGEs and their precursor compounds in CRC development.

KW - Advanced glycation end-products

KW - Colorectal cancer

KW - Dietary exposure

KW - Dietary glycation compounds

UR - http://www.scopus.com/inward/record.url?scp=85115008015&partnerID=8YFLogxK

U2 - 10.3390/nu13093132

DO - 10.3390/nu13093132

M3 - Article

C2 - 34579010

AN - SCOPUS:85115008015

SN - 2072-6643

VL - 13

JO - Nutrients

JF - Nutrients

IS - 9

M1 - 3132

ER -