TY - JOUR
T1 - Dilemma of first line regimens in metastatic pancreatic adenocarcinoma
AU - Ghosn, Marwan
AU - Ibrahim, Tony
AU - Assi, Tarek
AU - El Rassy, Elie
AU - Kourie, Hampig Raphael
AU - Kattan, Joseph
N1 - Publisher Copyright:
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
PY - 2016/12/14
Y1 - 2016/12/14
N2 - Pancreatic cancer is one of the deadliest cancers, ranking fourth among cancer-related deaths. Despite all the major molecular advances and treatment breakthroughs, mainly targeted therapies, the cornerstone treatment of metastatic pancreatic cancer (mPC) remains cytotoxic chemotherapy. In 2016, more than 40 years after the introduction of gemcitabine in the management of mPC, the best choice for first-line treatment has not yet been fully elucidated. Two main strategies have been adopted to enhance treatment efficacy. The first strategy is based on combining non-cross resistant drugs, while the second option includes the development of newer generations of chemotherapy. More recently, two new regimens, FOLFIRINOX and gemcitabine/nab-paclitaxel (GNP), have both been shown to improve overall survival in comparison with gemcitabine alone, at the cost of increased toxicity. Therefore, the best choice for first line therapy is a matter of debate. For some authors, FOLFIRINOX should be the first choice in patients with an Eastern Cooperative Oncology Group score (0-1) given its lower hazard ratio. However, others do not share this opinion. In this paper, we review the main comparison points between FOLFIRINOX and GNP. We analyze the two pivotal trials to determine the similarities and differences in study design. In addition, we compare the toxicity profile of the two regimens as well as the impact on quality of life. Finally, we present studies revealing real life experiences and review the advantages and disadvantages of possible second-line therapies including their cost effectiveness.
AB - Pancreatic cancer is one of the deadliest cancers, ranking fourth among cancer-related deaths. Despite all the major molecular advances and treatment breakthroughs, mainly targeted therapies, the cornerstone treatment of metastatic pancreatic cancer (mPC) remains cytotoxic chemotherapy. In 2016, more than 40 years after the introduction of gemcitabine in the management of mPC, the best choice for first-line treatment has not yet been fully elucidated. Two main strategies have been adopted to enhance treatment efficacy. The first strategy is based on combining non-cross resistant drugs, while the second option includes the development of newer generations of chemotherapy. More recently, two new regimens, FOLFIRINOX and gemcitabine/nab-paclitaxel (GNP), have both been shown to improve overall survival in comparison with gemcitabine alone, at the cost of increased toxicity. Therefore, the best choice for first line therapy is a matter of debate. For some authors, FOLFIRINOX should be the first choice in patients with an Eastern Cooperative Oncology Group score (0-1) given its lower hazard ratio. However, others do not share this opinion. In this paper, we review the main comparison points between FOLFIRINOX and GNP. We analyze the two pivotal trials to determine the similarities and differences in study design. In addition, we compare the toxicity profile of the two regimens as well as the impact on quality of life. Finally, we present studies revealing real life experiences and review the advantages and disadvantages of possible second-line therapies including their cost effectiveness.
KW - FOLFIRINOX
KW - Gemcitabine/nab-paclitaxel
KW - Metastatic pancreatic cancer
KW - Pivotal trials
KW - Review
UR - http://www.scopus.com/inward/record.url?scp=85006380195&partnerID=8YFLogxK
U2 - 10.3748/wjg.v22.i46.10124
DO - 10.3748/wjg.v22.i46.10124
M3 - Review article
C2 - 28028360
AN - SCOPUS:85006380195
SN - 1007-9327
VL - 22
SP - 10124
EP - 10130
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 46
ER -