Distinct MLL gene rearrangements associated with successive acute monocytic and lymphoblastic leukemias in the same patient

Philippe Jonveaux; Josette Hillion; Olivier Bernard; Maryvonne Le Coniat; Josette Derré; Maria Flexor; Christian Jacques Larsen; Roland Berger

Distinct MLL gene rearrangements associated with successive acute monocytic and lymphoblastic leukemias in the same patient

Philippe Jonveaux, Josette Hillion, Olivier Bernard, Maryvonne Le Coniat, Josette Derré, Maria Flexor, Christian Jacques Larsen, Roland Berger

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Résumé

A patient with acute monocytic leukemia (AMoL) and t(6;11)(q27;q23) developed acute lymphoblastic leukemia (ALL) and t(4;11)(q21;23), 10 months after complete remission of the AMoL. The MLL gene, normally located at band 11q23, appeared differently rearranged in the cells of these two leukemias, showing a different origin for the two malignant clones. The responsibility of etoposide, used in treatment of the AML, in the occurrence of the ALL is probable in this patient.

langue originale	Anglais
Pages (de - à)	2224-2227
Nombre de pages	4
journal	Leukemia
Volume	8
Numéro de publication	12
état	Publié - 1 janv. 1994

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title = "Distinct MLL gene rearrangements associated with successive acute monocytic and lymphoblastic leukemias in the same patient",

abstract = "A patient with acute monocytic leukemia (AMoL) and t(6;11)(q27;q23) developed acute lymphoblastic leukemia (ALL) and t(4;11)(q21;23), 10 months after complete remission of the AMoL. The MLL gene, normally located at band 11q23, appeared differently rearranged in the cells of these two leukemias, showing a different origin for the two malignant clones. The responsibility of etoposide, used in treatment of the AML, in the occurrence of the ALL is probable in this patient.",

author = "Philippe Jonveaux and Josette Hillion and Olivier Bernard and {Le Coniat}, Maryvonne and Josette Derr{\'e} and Maria Flexor and Larsen, {Christian Jacques} and Roland Berger",

year = "1994",

month = jan,

day = "1",

language = "English",

volume = "8",

pages = "2224--2227",

journal = "Leukemia",

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T1 - Distinct MLL gene rearrangements associated with successive acute monocytic and lymphoblastic leukemias in the same patient

AU - Jonveaux, Philippe

AU - Hillion, Josette

AU - Bernard, Olivier

AU - Le Coniat, Maryvonne

AU - Derré, Josette

AU - Flexor, Maria

AU - Larsen, Christian Jacques

AU - Berger, Roland

PY - 1994/1/1

Y1 - 1994/1/1

N2 - A patient with acute monocytic leukemia (AMoL) and t(6;11)(q27;q23) developed acute lymphoblastic leukemia (ALL) and t(4;11)(q21;23), 10 months after complete remission of the AMoL. The MLL gene, normally located at band 11q23, appeared differently rearranged in the cells of these two leukemias, showing a different origin for the two malignant clones. The responsibility of etoposide, used in treatment of the AML, in the occurrence of the ALL is probable in this patient.

AB - A patient with acute monocytic leukemia (AMoL) and t(6;11)(q27;q23) developed acute lymphoblastic leukemia (ALL) and t(4;11)(q21;23), 10 months after complete remission of the AMoL. The MLL gene, normally located at band 11q23, appeared differently rearranged in the cells of these two leukemias, showing a different origin for the two malignant clones. The responsibility of etoposide, used in treatment of the AML, in the occurrence of the ALL is probable in this patient.

UR - http://www.scopus.com/inward/record.url?scp=0028605288&partnerID=8YFLogxK

M3 - Article

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AN - SCOPUS:0028605288

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VL - 8

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EP - 2227

JO - Leukemia

JF - Leukemia

IS - 12

ER -