DNA methylation of hepatitis B virus (HBV) genome associated with the development of hepatocellular carcinoma and occult HBV infection

Pushpinder Kaur, Anupam Paliwal, David Durantel, Pierre Hainaut, Jean Yves Scoazec, Fabien Zoulim, Isabelle Chemin, Zdenko Herceg

Résultats de recherche: Contribution à un journalArticleRevue par des pairs

56 Citations (Scopus)

Résumé

Recent studies have identified the presence of methylation in the hepatitis B virus (HBV) genome and have suggested that it may be an important mechanism regulating transcription and replication of the HBV virus. However, it remains unclear whether this phenomenon is associated with occult hepatitis. Here, we performed a detailed analysis of DNA methylation in the HBV genome in liver samples of patients at different stages of hepatocarcinoma development and in in vitro infected hepatocytes and found discrete CpG sites in the HBV genome that are recurrently hypermethylated in cancer but not in chronic hepatitis tissue.

langue originaleAnglais
Pages (de - à)700-704
Nombre de pages5
journalJournal of Infectious Diseases
Volume202
Numéro de publication5
Les DOIs
étatPublié - 1 sept. 2010
Modification externeOui

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