TY - JOUR
T1 - DNA methylation of hepatitis B virus (HBV) genome associated with the development of hepatocellular carcinoma and occult HBV infection
AU - Kaur, Pushpinder
AU - Paliwal, Anupam
AU - Durantel, David
AU - Hainaut, Pierre
AU - Scoazec, Jean Yves
AU - Zoulim, Fabien
AU - Chemin, Isabelle
AU - Herceg, Zdenko
N1 - Funding Information:
Received 2 February 2010; accepted 1 April 2010; electronically published 23 July 2010. Financial support: International Agency for Research on Cancer (postdoctoral fellowship to P.K.), the Agence Nationale de Recherche Contre le Sida et Hépatites Virales, the Association pour la Recherche sur le Cancer, la Ligue Nationale (Franc¸aise) Contre le Cancer, and the Swiss Bridge Award. Potential conflicts of interest: none reported. a P.K. and A.P. contributed equally to this work. Reprints or correspondence: Zdenko Herceg, PhD, Epigenetics Group, International Agency for Research on Cancer (IARC), 150 Cours Albert-Thomas, F-69008 Lyon, France ([email protected]).
PY - 2010/9/1
Y1 - 2010/9/1
N2 - Recent studies have identified the presence of methylation in the hepatitis B virus (HBV) genome and have suggested that it may be an important mechanism regulating transcription and replication of the HBV virus. However, it remains unclear whether this phenomenon is associated with occult hepatitis. Here, we performed a detailed analysis of DNA methylation in the HBV genome in liver samples of patients at different stages of hepatocarcinoma development and in in vitro infected hepatocytes and found discrete CpG sites in the HBV genome that are recurrently hypermethylated in cancer but not in chronic hepatitis tissue.
AB - Recent studies have identified the presence of methylation in the hepatitis B virus (HBV) genome and have suggested that it may be an important mechanism regulating transcription and replication of the HBV virus. However, it remains unclear whether this phenomenon is associated with occult hepatitis. Here, we performed a detailed analysis of DNA methylation in the HBV genome in liver samples of patients at different stages of hepatocarcinoma development and in in vitro infected hepatocytes and found discrete CpG sites in the HBV genome that are recurrently hypermethylated in cancer but not in chronic hepatitis tissue.
UR - http://www.scopus.com/inward/record.url?scp=77955693084&partnerID=8YFLogxK
U2 - 10.1086/655398
DO - 10.1086/655398
M3 - Article
C2 - 20653444
AN - SCOPUS:77955693084
SN - 0022-1899
VL - 202
SP - 700
EP - 704
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 5
ER -