DNA methylation profiling reveals a predominant immune component in breast cancers

Sarah Dedeurwaerder; Christine Desmedt; Emilie Calonne; Sandeep K. Singhal; Benjamin Haibe-Kains; Matthieu Defrance; Stefan Michiels; Michael Volkmar; Rachel Deplus; Judith Luciani; Françoise Lallemand; Denis Larsimont; Jérôme Toussaint; Sandy Haussy; Françoise Rothé; Ghizlane Rouas; Otto Metzger; Samira Majjaj; Kamal Saini; Pascale Putmans; Gérald Hames; Nicolas van Baren; Pierre G. Coulie; Martine Piccart; Christos Sotiriou; François Fuks

doi:10.1002/emmm.201100801

DNA methylation profiling reveals a predominant immune component in breast cancers

Sarah Dedeurwaerder, Christine Desmedt, Emilie Calonne, Sandeep K. Singhal, Benjamin Haibe-Kains, Matthieu Defrance, Stefan Michiels, Michael Volkmar, Rachel Deplus, Judith Luciani, Françoise Lallemand, Denis Larsimont, Jérôme Toussaint, Sandy Haussy, Françoise Rothé, Ghizlane Rouas, Otto Metzger, Samira Majjaj, Kamal Saini, Pascale PutmansGérald Hames, Nicolas van Baren, Pierre G. Coulie, Martine Piccart, Christos Sotiriou, François Fuks

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

182 Citations (Scopus)

Résumé

Breast cancer is a molecularly, biologically and clinically heterogeneous group of disorders. Understanding this diversity is essential to improving diagnosis and optimizing treatment. Both genetic and acquired epigenetic abnormalities participate in cancer, but the involvement of the epigenome in breast cancer and its contribution to the complexity of the disease are still poorly understood. By means of DNA methylation profiling of 248 breast tissues, we have highlighted the existence of previously unrecognized breast cancer groups that go beyond the currently known 'expression subtypes'. Interestingly, we showed that DNA methylation profiling can reflect the cell type composition of the tumour microenvironment, and in particular a T lymphocyte infiltration of the tumours. Further, we highlighted a set of immune genes having high prognostic value in specific tumour categories. The immune component uncovered here by DNA methylation profiles provides a new perspective for the importance of the microenvironment in breast cancer, holding implications for better management of breast cancer patients.

langue originale	Anglais
Pages (de - à)	726-741
Nombre de pages	16
journal	EMBO Molecular Medicine
Volume	3
Numéro de publication	12
Les DOIs	https://doi.org/10.1002/emmm.201100801
état	Publié - 1 déc. 2011
Modification externe	Oui

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10.1002/emmm.201100801

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Dedeurwaerder, S., Desmedt, C., Calonne, E., Singhal, S. K., Haibe-Kains, B., Defrance, M., Michiels, S., Volkmar, M., Deplus, R., Luciani, J., Lallemand, F., Larsimont, D., Toussaint, J., Haussy, S., Rothé, F., Rouas, G., Metzger, O., Majjaj, S., Saini, K., ... Fuks, F. (2011). DNA methylation profiling reveals a predominant immune component in breast cancers. EMBO Molecular Medicine, 3(12), 726-741. https://doi.org/10.1002/emmm.201100801

@article{ca1dec2fc127499092dd131cf422321b,

title = "DNA methylation profiling reveals a predominant immune component in breast cancers",

abstract = "Breast cancer is a molecularly, biologically and clinically heterogeneous group of disorders. Understanding this diversity is essential to improving diagnosis and optimizing treatment. Both genetic and acquired epigenetic abnormalities participate in cancer, but the involvement of the epigenome in breast cancer and its contribution to the complexity of the disease are still poorly understood. By means of DNA methylation profiling of 248 breast tissues, we have highlighted the existence of previously unrecognized breast cancer groups that go beyond the currently known 'expression subtypes'. Interestingly, we showed that DNA methylation profiling can reflect the cell type composition of the tumour microenvironment, and in particular a T lymphocyte infiltration of the tumours. Further, we highlighted a set of immune genes having high prognostic value in specific tumour categories. The immune component uncovered here by DNA methylation profiles provides a new perspective for the importance of the microenvironment in breast cancer, holding implications for better management of breast cancer patients.",

keywords = "Breast cancer, DNA methylation, Epigenetics, Epigenomics, Microenvironment",

author = "Sarah Dedeurwaerder and Christine Desmedt and Emilie Calonne and Singhal, {Sandeep K.} and Benjamin Haibe-Kains and Matthieu Defrance and Stefan Michiels and Michael Volkmar and Rachel Deplus and Judith Luciani and Fran{\c c}oise Lallemand and Denis Larsimont and J{\'e}r{\^o}me Toussaint and Sandy Haussy and Fran{\c c}oise Roth{\'e} and Ghizlane Rouas and Otto Metzger and Samira Majjaj and Kamal Saini and Pascale Putmans and G{\'e}rald Hames and {van Baren}, Nicolas and Coulie, {Pierre G.} and Martine Piccart and Christos Sotiriou and Fran{\c c}ois Fuks",

year = "2011",

month = dec,

day = "1",

doi = "10.1002/emmm.201100801",

language = "English",

volume = "3",

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Dedeurwaerder, S, Desmedt, C, Calonne, E, Singhal, SK, Haibe-Kains, B, Defrance, M, Michiels, S, Volkmar, M, Deplus, R, Luciani, J, Lallemand, F, Larsimont, D, Toussaint, J, Haussy, S, Rothé, F, Rouas, G, Metzger, O, Majjaj, S, Saini, K, Putmans, P, Hames, G, van Baren, N, Coulie, PG, Piccart, M, Sotiriou, C & Fuks, F 2011, 'DNA methylation profiling reveals a predominant immune component in breast cancers', EMBO Molecular Medicine, VOL. 3, Numéro 12, p. 726-741. https://doi.org/10.1002/emmm.201100801

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T1 - DNA methylation profiling reveals a predominant immune component in breast cancers

AU - Dedeurwaerder, Sarah

AU - Desmedt, Christine

AU - Calonne, Emilie

AU - Singhal, Sandeep K.

AU - Haibe-Kains, Benjamin

AU - Defrance, Matthieu

AU - Michiels, Stefan

AU - Volkmar, Michael

AU - Deplus, Rachel

AU - Luciani, Judith

AU - Lallemand, Françoise

AU - Larsimont, Denis

AU - Toussaint, Jérôme

AU - Haussy, Sandy

AU - Rothé, Françoise

AU - Rouas, Ghizlane

AU - Metzger, Otto

AU - Majjaj, Samira

AU - Saini, Kamal

AU - Putmans, Pascale

AU - Hames, Gérald

AU - van Baren, Nicolas

AU - Coulie, Pierre G.

AU - Piccart, Martine

AU - Sotiriou, Christos

AU - Fuks, François

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Breast cancer is a molecularly, biologically and clinically heterogeneous group of disorders. Understanding this diversity is essential to improving diagnosis and optimizing treatment. Both genetic and acquired epigenetic abnormalities participate in cancer, but the involvement of the epigenome in breast cancer and its contribution to the complexity of the disease are still poorly understood. By means of DNA methylation profiling of 248 breast tissues, we have highlighted the existence of previously unrecognized breast cancer groups that go beyond the currently known 'expression subtypes'. Interestingly, we showed that DNA methylation profiling can reflect the cell type composition of the tumour microenvironment, and in particular a T lymphocyte infiltration of the tumours. Further, we highlighted a set of immune genes having high prognostic value in specific tumour categories. The immune component uncovered here by DNA methylation profiles provides a new perspective for the importance of the microenvironment in breast cancer, holding implications for better management of breast cancer patients.

AB - Breast cancer is a molecularly, biologically and clinically heterogeneous group of disorders. Understanding this diversity is essential to improving diagnosis and optimizing treatment. Both genetic and acquired epigenetic abnormalities participate in cancer, but the involvement of the epigenome in breast cancer and its contribution to the complexity of the disease are still poorly understood. By means of DNA methylation profiling of 248 breast tissues, we have highlighted the existence of previously unrecognized breast cancer groups that go beyond the currently known 'expression subtypes'. Interestingly, we showed that DNA methylation profiling can reflect the cell type composition of the tumour microenvironment, and in particular a T lymphocyte infiltration of the tumours. Further, we highlighted a set of immune genes having high prognostic value in specific tumour categories. The immune component uncovered here by DNA methylation profiles provides a new perspective for the importance of the microenvironment in breast cancer, holding implications for better management of breast cancer patients.

KW - Breast cancer

KW - DNA methylation

KW - Epigenetics

KW - Epigenomics

KW - Microenvironment

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SN - 1757-4676

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JO - EMBO Molecular Medicine

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