Docetaxel and gemcitabine combination in 133 advanced soft-tissue sarcomas: A retrospective analysis

Jacques Olivier Bay, Isabelle Ray-Coquard, Jérôme Fayette, Serge Leyvraz, Stephane Cherix, Sophie Piperno-Neumann, Christine Chevreau, Nicolas Isambert, Etienne Brain, Georges Emile, Axel Le Cesne, Angela Cioffi, Fabrice Kwiatkowski, Jean Michel Coindre, Nguyon Binh Bui, Frédéric Peyrade, Jean Yves Blay

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    168 Citations (Scopus)

    Résumé

    Advanced soft-tissue sarcomas are usually resistant to cytotoxic agents such as doxorubicin and ifosfamide. Antitumor activity has been observed for gemcitabine and docetaxel combination. We conducted a retrospective study on 133 patients (58 males/75 females) with unresectable or metastatic soft-tissue sarcoma. The median age at diagnosis was 51.7 (18-82), with 76 patients with leiomoyosarcoma and 57 patients with other histological subtypes. The initial localizations were limb (44), uterine (32), retroperitoneal (23) and organs or bone (34). Patients received 900 mg/m2 of gemcitabine (days 1 and 8) over 90 min plus 100 mg/m2 of docetaxel (day 8), intravenously every 21 days. Gemcitabine/docetaxel combination was well tolerated with an overall response of 18.4% and with no clear statistical difference between leiomyosarcomas and other histological subtypes (24.2% versus 10.4% (p = 0.06)). No difference was found between uterine soft-tissue sarcomas versus others. The median overall survival was 12.1 months (1-28). Better overall survival was correlated with leiomyosarcoma (p = 0.01) and with the quality of the response, even for patients with stable disease (p < 10-4). No statistical difference was found for the initial localization. Response to treatment and overall survival were better for patients in World Health Organization (WHO) performance status classification (PS) 0 at baseline versus patients in WHO PS-1, 2 or 3 (p = 0.023 and p < 10-4, respectively). Gemcitabine/docetaxel combination was tolerable and demonstrated better response and survival for leiomyosarcoma, especially for patients in WHO PS-0 at baseline. For the other histological subtypes, the response was not encouraging, but the survival for patients in response or stable suggests further investigation.

    langue originaleAnglais
    Pages (de - à)706-711
    Nombre de pages6
    journalInternational Journal of Cancer
    Volume119
    Numéro de publication3
    Les DOIs
    étatPublié - 1 août 2006

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