Données actuelles des associations chimioradiothérapeutiques et place potentielle des thérapies ciblées dans les cancers du col utérin

N. Magné, E. Deutsch, C. Haie-Meder

    Résultats de recherche: Contribution à un journalBrève enquêteRevue par des pairs

    12 Citations (Scopus)

    Résumé

    The present review represents an up-to-date focus on the particular topic of cervix carcinoma. An exhaustive description of the actual data and the near-future combination of radiotherapy and drugs with the specific potential of targeted therapies are presented. This approach represents one of the next challenges to improve results. Studies conducted in 1999, 2000, and 2002 reported the results of six large-scale prospective randomized trials using concomitant chemoradiation with a significant progression-free and overall survival rate improvement compared to radiotherapy only. These results were confirmed by the two last meta-analyses. Nowadays, the concurrent radiochemotherapy schedule used in the treatment of high risk cervical cancer is a standard practice. More growing evidences suggest that intracellular signal pathways play a significant role in radiation response. Several prognostic factors on tumoral radiosensitivity have been identified, including intracellular signal pathways, in the particular case of cervix carcinoma. Promising results have been obtained in experimental studies assessing the combined use of specific inhibitors and radiotherapy. Based on these data, a number of clinical trials have been started to enhance tumor responses and thus, to decrease the rate of recurrences.

    Titre traduit de la contributionCurrent data of combination of radiotherapy and drugs with special potential of targeted therapies in cervical cancer
    langue originaleFrançais
    Pages (de - à)31-36
    Nombre de pages6
    journalCancer/Radiotherapie
    Volume12
    Numéro de publication1
    Les DOIs
    étatPublié - 1 janv. 2008

    mots-clés

    • Cervix carcinoma
    • Radiochemotherapy
    • Radiosensitizing effect
    • Radiotherapy
    • Targeted therapies

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