TY - JOUR
T1 - Doppler US with perfusion software and contrast medium injection in the early evaluation of radiofrequency in breast cancer recurrences
T2 - A prospective phase II study
AU - Lamuraglia, Michele
AU - Lassau, Nathalie
AU - Garbay, Jean Remi
AU - Mathieu, Marie Christine
AU - Rouzier, Romain
AU - Jaziri, Sofiene
AU - Roche, Alain
AU - Leclere, Jerome
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Introduction: The aim of this study was to determine the efficacy of Doppler ultrasonography (US) with perfusion software and contrast agent injection (DUPC) during radiofrequency (RF) treatment of local recurrent breast cancer. Materials and Methods: Ten patients were included in this monocentric prospective phase II study. DUPC was performed for each patient the day before treatment and immediately after RF in the operating suite. RF ablation was followed by a total mastectomy. The results of DUPC were compared to the histologic analysis of the operative specimen. Results: Before RF, contrast uptake exceeded 70% in 5 lesions and was less than 50% in 5 lesions. Immediately after RF, no vascularization was detected with DUPC in 9 of the 10 lesions. Contrast uptake attaining 30% was depicted in the remaining lesion. At histologic analysis, complete tumour destruction was confirmed in 7 of the 10 operative specimens. Conclusion: In this study, DUPC is highly efficient and better adapted for the confirmation of tumour destruction in tumours that are hypervascularised before RF compared to hypovascularised lesions.
AB - Introduction: The aim of this study was to determine the efficacy of Doppler ultrasonography (US) with perfusion software and contrast agent injection (DUPC) during radiofrequency (RF) treatment of local recurrent breast cancer. Materials and Methods: Ten patients were included in this monocentric prospective phase II study. DUPC was performed for each patient the day before treatment and immediately after RF in the operating suite. RF ablation was followed by a total mastectomy. The results of DUPC were compared to the histologic analysis of the operative specimen. Results: Before RF, contrast uptake exceeded 70% in 5 lesions and was less than 50% in 5 lesions. Immediately after RF, no vascularization was detected with DUPC in 9 of the 10 lesions. Contrast uptake attaining 30% was depicted in the remaining lesion. At histologic analysis, complete tumour destruction was confirmed in 7 of the 10 operative specimens. Conclusion: In this study, DUPC is highly efficient and better adapted for the confirmation of tumour destruction in tumours that are hypervascularised before RF compared to hypovascularised lesions.
KW - Breast cancer
KW - Contrast medium
KW - Radiofrequency (RF)
KW - Ultrasound (US)
UR - http://www.scopus.com/inward/record.url?scp=27844556962&partnerID=8YFLogxK
U2 - 10.1016/j.ejrad.2005.06.003
DO - 10.1016/j.ejrad.2005.06.003
M3 - Article
C2 - 16005593
AN - SCOPUS:27844556962
SN - 0720-048X
VL - 56
SP - 376
EP - 381
JO - European Journal of Radiology
JF - European Journal of Radiology
IS - 3
ER -