Early onset of chemotherapy can reduce the incidence of ATRA syndrome in newly diagnosed acute promyelocytic leukemia (APL) with low white blood cell counts: Results from APL 93 trial

S. de Botton; S. Chevret; V. Coiteux; H. Dombret; M. Sanz; J. San Miguel; D. Caillot; A. Vekhoff; M. Gardembas; A. Stamatoulas; E. Conde; A. Guerci; C. Gardin; M. Fey; D. Cony Makhoul; O. Reman; J. de la Serna; F. Lefrere; C. Chomienne; L. Degos; P. Fenaux; S. Castaigne; R. Zittoun; E. Archimbaud; P. Travade; C. Gardin; A. Guerci; A. M. Stoppa; F. Dreyfus; F. Stamatoulas; F. Rigal-Huguet; H. Guy; J. J. Sotto; F. Maloisel; J. Reiffers; A. Gardembas; D. Bordessoule; N. Fegueux; A. Veil; T. Lamy; M. Hayat; E. Deconinck; E. Guyotat; M. Martin; E. Cony-Makhoul; J. P. Abgrall; O. Reman; B. Desablens; J. L. Harousseau; Y. Bastion; J. P. Pollet

doi:10.1038/sj.leu.2402807

Early onset of chemotherapy can reduce the incidence of ATRA syndrome in newly diagnosed acute promyelocytic leukemia (APL) with low white blood cell counts: Results from APL 93 trial

S. de Botton, S. Chevret, V. Coiteux, H. Dombret, M. Sanz, J. San Miguel, D. Caillot, A. Vekhoff, M. Gardembas, A. Stamatoulas, E. Conde, A. Guerci, C. Gardin, M. Fey, D. Cony Makhoul, O. Reman, J. de la Serna, F. Lefrere, C. Chomienne, L. DegosP. Fenaux, S. Castaigne, R. Zittoun, E. Archimbaud, P. Travade, C. Gardin, A. Guerci, A. M. Stoppa, F. Dreyfus, F. Stamatoulas, F. Rigal-Huguet, H. Guy, J. J. Sotto, F. Maloisel, J. Reiffers, A. Gardembas, D. Bordessoule, N. Fegueux, A. Veil, T. Lamy, M. Hayat, E. Deconinck, E. Guyotat, M. Martin, E. Cony-Makhoul, J. P. Abgrall, O. Reman, B. Desablens, J. L. Harousseau, Y. Bastion, J. P. Pollet

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Résumé

Treatment combining ATRA and chemotherapy (CT) has improved the outcome of APL patients, by comparison with CT alone. ATRA syndrome is a life-threatening complication of ATRA treatment whose prophylaxis remains somewhat controversial. In APL93 trial, newly diagnosed APL patients ≤65 years and with initial WBC counts below 5000/mm³ were randomized between ATRA until CR achievement followed by CT (ATRA → CT) and-ATRA with early addition of CT, on day 3 of ATRA treatment (ATRA + CT). The incidence of ATRA syndrome in the ATRA → CT arm was 18% (22/122) as compared to 9.2% (17/184) in the ATRA + CT arm (P = 0.035). In the ATRA → CT arm, three (2.5%) patients died from ATRA syndrome, as compared to one (0.5%) in the ATRA + CT group. Early addition of chemotherapy to ATRA in newly diagnosed APL with low WBC counts significantly reduced the incidence of ATRA syndrome.

langue originale	Anglais
Pages (de - à)	339-342
Nombre de pages	4
journal	Leukemia
Volume	17
Numéro de publication	2
Les DOIs	https://doi.org/10.1038/sj.leu.2402807
état	Publié - 1 févr. 2003

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10.1038/sj.leu.2402807

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de Botton, S., Chevret, S., Coiteux, V., Dombret, H., Sanz, M., San Miguel, J., Caillot, D., Vekhoff, A., Gardembas, M., Stamatoulas, A., Conde, E., Guerci, A., Gardin, C., Fey, M., Cony Makhoul, D., Reman, O., de la Serna, J., Lefrere, F., Chomienne, C., ... Pollet, J. P. (2003). Early onset of chemotherapy can reduce the incidence of ATRA syndrome in newly diagnosed acute promyelocytic leukemia (APL) with low white blood cell counts: Results from APL 93 trial. Leukemia, 17(2), 339-342. https://doi.org/10.1038/sj.leu.2402807

@article{9f2ab5c650a24a339502044abbd94bb4,

title = "Early onset of chemotherapy can reduce the incidence of ATRA syndrome in newly diagnosed acute promyelocytic leukemia (APL) with low white blood cell counts: Results from APL 93 trial",

abstract = "Treatment combining ATRA and chemotherapy (CT) has improved the outcome of APL patients, by comparison with CT alone. ATRA syndrome is a life-threatening complication of ATRA treatment whose prophylaxis remains somewhat controversial. In APL93 trial, newly diagnosed APL patients ≤65 years and with initial WBC counts below 5000/mm3 were randomized between ATRA until CR achievement followed by CT (ATRA → CT) and-ATRA with early addition of CT, on day 3 of ATRA treatment (ATRA + CT). The incidence of ATRA syndrome in the ATRA → CT arm was 18% (22/122) as compared to 9.2% (17/184) in the ATRA + CT arm (P = 0.035). In the ATRA → CT arm, three (2.5%) patients died from ATRA syndrome, as compared to one (0.5%) in the ATRA + CT group. Early addition of chemotherapy to ATRA in newly diagnosed APL with low WBC counts significantly reduced the incidence of ATRA syndrome.",

keywords = "ATRA syndrome, Acute promyelocytic leukemia, Prophylaxis chemotherapy",

author = "{de Botton}, S. and S. Chevret and V. Coiteux and H. Dombret and M. Sanz and {San Miguel}, J. and D. Caillot and A. Vekhoff and M. Gardembas and A. Stamatoulas and E. Conde and A. Guerci and C. Gardin and M. Fey and {Cony Makhoul}, D. and O. Reman and {de la Serna}, J. and F. Lefrere and C. Chomienne and L. Degos and P. Fenaux and S. Castaigne and R. Zittoun and E. Archimbaud and P. Travade and C. Gardin and A. Guerci and Stoppa, {A. M.} and F. Dreyfus and F. Stamatoulas and F. Rigal-Huguet and H. Guy and Sotto, {J. J.} and F. Maloisel and J. Reiffers and A. Gardembas and D. Bordessoule and N. Fegueux and A. Veil and T. Lamy and M. Hayat and E. Deconinck and E. Guyotat and M. Martin and E. Cony-Makhoul and Abgrall, {J. P.} and O. Reman and B. Desablens and Harousseau, {J. L.} and Y. Bastion and Pollet, {J. P.}",

note = "Funding Information: Supported by the Programme Hospitalier de Recherche Clinique (CHU Lille), the Association de Recherche contre le Cancer and the Ligue nationale contre le Cancer (Comit{\'e} du Nord).",

year = "2003",

month = feb,

day = "1",

doi = "10.1038/sj.leu.2402807",

language = "English",

volume = "17",

pages = "339--342",

journal = "Leukemia",

issn = "0887-6924",

number = "2",

}

de Botton, S, Chevret, S, Coiteux, V, Dombret, H, Sanz, M, San Miguel, J, Caillot, D, Vekhoff, A, Gardembas, M, Stamatoulas, A, Conde, E, Guerci, A, Gardin, C, Fey, M, Cony Makhoul, D, Reman, O, de la Serna, J, Lefrere, F, Chomienne, C, Degos, L, Fenaux, P, Castaigne, S, Zittoun, R, Archimbaud, E, Travade, P, Gardin, C, Guerci, A, Stoppa, AM, Dreyfus, F, Stamatoulas, F, Rigal-Huguet, F, Guy, H, Sotto, JJ, Maloisel, F, Reiffers, J, Gardembas, A, Bordessoule, D, Fegueux, N, Veil, A, Lamy, T, Hayat, M, Deconinck, E, Guyotat, E, Martin, M, Cony-Makhoul, E, Abgrall, JP, Reman, O, Desablens, B, Harousseau, JL, Bastion, Y & Pollet, JP 2003, 'Early onset of chemotherapy can reduce the incidence of ATRA syndrome in newly diagnosed acute promyelocytic leukemia (APL) with low white blood cell counts: Results from APL 93 trial', Leukemia, VOL. 17, Numéro 2, p. 339-342. https://doi.org/10.1038/sj.leu.2402807

Early onset of chemotherapy can reduce the incidence of ATRA syndrome in newly diagnosed acute promyelocytic leukemia (APL) with low white blood cell counts: Results from APL 93 trial. / de Botton, S.; Chevret, S.; Coiteux, V. et al.
Dans: Leukemia, Vol 17, Numéro 2, 01.02.2003, p. 339-342.

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

TY - JOUR

T1 - Early onset of chemotherapy can reduce the incidence of ATRA syndrome in newly diagnosed acute promyelocytic leukemia (APL) with low white blood cell counts

T2 - Results from APL 93 trial

AU - de Botton, S.

AU - Chevret, S.

AU - Coiteux, V.

AU - Dombret, H.

AU - Sanz, M.

AU - San Miguel, J.

AU - Caillot, D.

AU - Vekhoff, A.

AU - Gardembas, M.

AU - Stamatoulas, A.

AU - Conde, E.

AU - Guerci, A.

AU - Gardin, C.

AU - Fey, M.

AU - Cony Makhoul, D.

AU - Reman, O.

AU - de la Serna, J.

AU - Lefrere, F.

AU - Chomienne, C.

AU - Degos, L.

AU - Fenaux, P.

AU - Castaigne, S.

AU - Zittoun, R.

AU - Archimbaud, E.

AU - Travade, P.

AU - Gardin, C.

AU - Guerci, A.

AU - Stoppa, A. M.

AU - Dreyfus, F.

AU - Stamatoulas, F.

AU - Rigal-Huguet, F.

AU - Guy, H.

AU - Sotto, J. J.

AU - Maloisel, F.

AU - Reiffers, J.

AU - Gardembas, A.

AU - Bordessoule, D.

AU - Fegueux, N.

AU - Veil, A.

AU - Lamy, T.

AU - Hayat, M.

AU - Deconinck, E.

AU - Guyotat, E.

AU - Martin, M.

AU - Cony-Makhoul, E.

AU - Abgrall, J. P.

AU - Reman, O.

AU - Desablens, B.

AU - Harousseau, J. L.

AU - Bastion, Y.

AU - Pollet, J. P.

N1 - Funding Information: Supported by the Programme Hospitalier de Recherche Clinique (CHU Lille), the Association de Recherche contre le Cancer and the Ligue nationale contre le Cancer (Comité du Nord).

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Treatment combining ATRA and chemotherapy (CT) has improved the outcome of APL patients, by comparison with CT alone. ATRA syndrome is a life-threatening complication of ATRA treatment whose prophylaxis remains somewhat controversial. In APL93 trial, newly diagnosed APL patients ≤65 years and with initial WBC counts below 5000/mm3 were randomized between ATRA until CR achievement followed by CT (ATRA → CT) and-ATRA with early addition of CT, on day 3 of ATRA treatment (ATRA + CT). The incidence of ATRA syndrome in the ATRA → CT arm was 18% (22/122) as compared to 9.2% (17/184) in the ATRA + CT arm (P = 0.035). In the ATRA → CT arm, three (2.5%) patients died from ATRA syndrome, as compared to one (0.5%) in the ATRA + CT group. Early addition of chemotherapy to ATRA in newly diagnosed APL with low WBC counts significantly reduced the incidence of ATRA syndrome.

AB - Treatment combining ATRA and chemotherapy (CT) has improved the outcome of APL patients, by comparison with CT alone. ATRA syndrome is a life-threatening complication of ATRA treatment whose prophylaxis remains somewhat controversial. In APL93 trial, newly diagnosed APL patients ≤65 years and with initial WBC counts below 5000/mm3 were randomized between ATRA until CR achievement followed by CT (ATRA → CT) and-ATRA with early addition of CT, on day 3 of ATRA treatment (ATRA + CT). The incidence of ATRA syndrome in the ATRA → CT arm was 18% (22/122) as compared to 9.2% (17/184) in the ATRA + CT arm (P = 0.035). In the ATRA → CT arm, three (2.5%) patients died from ATRA syndrome, as compared to one (0.5%) in the ATRA + CT group. Early addition of chemotherapy to ATRA in newly diagnosed APL with low WBC counts significantly reduced the incidence of ATRA syndrome.

KW - ATRA syndrome

KW - Acute promyelocytic leukemia

KW - Prophylaxis chemotherapy

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U2 - 10.1038/sj.leu.2402807

DO - 10.1038/sj.leu.2402807

M3 - Article

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JO - Leukemia

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