Résumé
Experimental and clinical findings suggest that low molecular-weight heparins may improve overall survival in patients with cancer. The evidence is still limited and additional studies are needed to confirm these preliminary findings. Methods. Patients with completely resected stage I, II or IIIA (T3N1) histologically confirmed non-small-cell lung cancer will be included in a prospective, controlled, randomized, multicenter open trial. Patients in the control group will receive usual postoperative care including chemotherapy when indicated. Patients in the experimental group will receive tinzaparin given subcutaneously as a daily 100 IU/kg dose for 90 days along with usual postoperative care. Patients will be followed-up for three to eight years. Main end-point is the overall survival. Five hundred and fifty patients are needed to demonstrate a 10% absolute increase in survival in the experimental group. Expected results. A 10% absolute increase in the survival rate is expected in the patients receiving tinzaparin.
Titre traduit de la contribution | Effect of tinzaparin on survival in non-small-cell lung cancer after surgery. TILT: Tinzaparin in lung tumours |
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langue originale | Français |
Pages (de - à) | 654-659 |
Nombre de pages | 6 |
journal | Revue des Maladies Respiratoires |
Volume | 28 |
Numéro de publication | 5 |
Les DOIs | |
état | Publié - 1 mai 2011 |
mots-clés
- Adjuvant therapy
- Heparin
- Non-small-cell lung cancer
- Survival
- Tinzaparin