Efficacy and safety of trabectedin as an early treatment for advanced or metastatic liposarcoma and leiomyosarcoma

Jean Yves Blay, Paolo Casali, Antonio Nieto, Adnan Tanović, Axel Le Cesne

    Résultats de recherche: Contribution à un journalArticleRevue par des pairs

    26 Citations (Scopus)

    Résumé

    Aims: We aimed to evaluate the effect of prior chemotherapies on the outcomes of patients with liposarcoma and leiomyosarcoma treated with trabectedin as a 24-h infusion every 3 weeks. Patients & methods: Data from 129 patients who received trabectedin as second-line treatment following failure with an anthracycline/ifosfamide and those who had received at least two lines of prior chemotherapy were analyzed. Results: Forty seven patients received one prior regimen (group A) and 82 patients received at least two lines of chemotherapy (group B). A favorable trend in median time to progression (4.4 vs 3.0 months), progression-free survival (4.4 vs 2.6 months) and overall survival (17.4 vs 13.3 months) was found in group A. A trend toward higher overall response rate (6.4 vs 4.9%) and disease control rate (34.0 vs 26.8%) also favored group A. Both groups had equivalent safety profiles. Conclusion: All efficacy outcomes were better in patients who received trabectedin as second-line treatment compared with patients with more extensive prior therapy.

    langue originaleAnglais
    Pages (de - à)59-68
    Nombre de pages10
    journalFuture Oncology
    Volume10
    Numéro de publication1
    Les DOIs
    étatPublié - 1 janv. 2014

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