eIF2α phosphorylation: A hallmark of immunogenic cell death

Lucillia Bezu; Allan Sauvat; Juliette Humeau; Marion Leduc; Oliver Kepp; Guido Kroemer

doi:10.1080/2162402X.2018.1431089

eIF2α phosphorylation: A hallmark of immunogenic cell death

Lucillia Bezu, Allan Sauvat, Juliette Humeau, Marion Leduc, Oliver Kepp, Guido Kroemer

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Résumé

Immunogenic cell death (ICD) induced by anticancer chemotherapeutics is usually preceded by premortem stress affecting the endoplasmic reticulum (ER). This ER stress does not reflect a canonical unfolded protein response (UPR) but rather manifests solely at the level of the phosphorylation of eIF2α. eIF2α phosphorylation is hence a quintessential hallmark of ICD that can be detected by immunohistochemistry in tumor samples.

langue originale	Anglais
Numéro d'article	e1431089
journal	OncoImmunology
Volume	7
Numéro de publication	6
Les DOIs	https://doi.org/10.1080/2162402X.2018.1431089
état	Publié - 3 juin 2018

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10.1080/2162402X.2018.1431089

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title = "eIF2α phosphorylation: A hallmark of immunogenic cell death",

abstract = "Immunogenic cell death (ICD) induced by anticancer chemotherapeutics is usually preceded by premortem stress affecting the endoplasmic reticulum (ER). This ER stress does not reflect a canonical unfolded protein response (UPR) but rather manifests solely at the level of the phosphorylation of eIF2α. eIF2α phosphorylation is hence a quintessential hallmark of ICD that can be detected by immunohistochemistry in tumor samples.",

keywords = "ER stress, anthracyclines, cancer, chemotherapy, unfolded protein response",

author = "Lucillia Bezu and Allan Sauvat and Juliette Humeau and Marion Leduc and Oliver Kepp and Guido Kroemer",

note = "Publisher Copyright: {\textcopyright} 2018 Taylor & Francis Group, LLC.",

year = "2018",

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doi = "10.1080/2162402X.2018.1431089",

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AU - Bezu, Lucillia

AU - Sauvat, Allan

AU - Humeau, Juliette

AU - Leduc, Marion

AU - Kepp, Oliver

AU - Kroemer, Guido

PY - 2018/6/3

Y1 - 2018/6/3

N2 - Immunogenic cell death (ICD) induced by anticancer chemotherapeutics is usually preceded by premortem stress affecting the endoplasmic reticulum (ER). This ER stress does not reflect a canonical unfolded protein response (UPR) but rather manifests solely at the level of the phosphorylation of eIF2α. eIF2α phosphorylation is hence a quintessential hallmark of ICD that can be detected by immunohistochemistry in tumor samples.

AB - Immunogenic cell death (ICD) induced by anticancer chemotherapeutics is usually preceded by premortem stress affecting the endoplasmic reticulum (ER). This ER stress does not reflect a canonical unfolded protein response (UPR) but rather manifests solely at the level of the phosphorylation of eIF2α. eIF2α phosphorylation is hence a quintessential hallmark of ICD that can be detected by immunohistochemistry in tumor samples.

KW - ER stress

KW - anthracyclines

KW - cancer

KW - chemotherapy

KW - unfolded protein response

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