Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19

Aymeric Silvin; Nicolas Chapuis; Garett Dunsmore; Anne Gaëlle Goubet; Agathe Dubuisson; Lisa Derosa; Carole Almire; Clémence Hénon; Olivier Kosmider; Nathalie Droin; Philippe Rameau; Cyril Catelain; Alexia Alfaro; Charles Dussiau; Chloé Friedrich; Elise Sourdeau; Nathalie Marin; Tali Anne Szwebel; Delphine Cantin; Luc Mouthon; Didier Borderie; Marc Deloger; Delphine Bredel; Severine Mouraud; Damien Drubay; Muriel Andrieu; Anne Sophie Lhonneur; Véronique Saada; Annabelle Stoclin; Christophe Willekens; Fanny Pommeret; Frank Griscelli; Lai Guan Ng; Zheng Zhang; Pierre Bost; Ido Amit; Fabrice Barlesi; Aurélien Marabelle; Frédéric Pène; Bertrand Gachot; Fabrice André; Laurence Zitvogel; Florent Ginhoux; Michaela Fontenay; Eric Solary

doi:10.1016/j.cell.2020.08.002

Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19

Aymeric Silvin, Nicolas Chapuis, Garett Dunsmore, Anne Gaëlle Goubet, Agathe Dubuisson, Lisa Derosa, Carole Almire, Clémence Hénon, Olivier Kosmider, Nathalie Droin, Philippe Rameau, Cyril Catelain, Alexia Alfaro, Charles Dussiau, Chloé Friedrich, Elise Sourdeau, Nathalie Marin, Tali Anne Szwebel, Delphine Cantin, Luc MouthonDidier Borderie, Marc Deloger, Delphine Bredel, Severine Mouraud, Damien Drubay, Muriel Andrieu, Anne Sophie Lhonneur, Véronique Saada, Annabelle Stoclin, Christophe Willekens, Fanny Pommeret, Frank Griscelli, Lai Guan Ng, Zheng Zhang, Pierre Bost, Ido Amit, Fabrice Barlesi, Aurélien Marabelle, Frédéric Pène, Bertrand Gachot, Fabrice André, Laurence Zitvogel, Florent Ginhoux, Michaela Fontenay, Eric Solary

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

599 Citations (Scopus)

Résumé

An analysis of patients with severe COVID-19 reveals immature neutrophil and non-classical monocyte pools, with levels of the protein calprotectin linked to disease severity.

langue originale	Anglais
Pages (de - à)	1401-1418.e18
journal	Cell
Volume	182
Numéro de publication	6
Les DOIs	https://doi.org/10.1016/j.cell.2020.08.002
état	Publié - 17 sept. 2020

Accès au document

10.1016/j.cell.2020.08.002

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Silvin, A., Chapuis, N., Dunsmore, G., Goubet, A. G., Dubuisson, A., Derosa, L., Almire, C., Hénon, C., Kosmider, O., Droin, N., Rameau, P., Catelain, C., Alfaro, A., Dussiau, C., Friedrich, C., Sourdeau, E., Marin, N., Szwebel, T. A., Cantin, D., ... Solary, E. (2020). Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19. Cell, 182(6), 1401-1418.e18. https://doi.org/10.1016/j.cell.2020.08.002

@article{e5e77696bd2d4fc893e212c6f5349854,

title = "Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19",

abstract = "An analysis of patients with severe COVID-19 reveals immature neutrophil and non-classical monocyte pools, with levels of the protein calprotectin linked to disease severity.",

keywords = "COVID-19, S100A8, S100A9, SARS-CoV-2, calprotectin, emergency myelopoiesis, monocyte subsets, neutrophils, type I interferon",

author = "Aymeric Silvin and Nicolas Chapuis and Garett Dunsmore and Goubet, {Anne Ga{\"e}lle} and Agathe Dubuisson and Lisa Derosa and Carole Almire and Cl{\'e}mence H{\'e}non and Olivier Kosmider and Nathalie Droin and Philippe Rameau and Cyril Catelain and Alexia Alfaro and Charles Dussiau and Chlo{\'e} Friedrich and Elise Sourdeau and Nathalie Marin and Szwebel, {Tali Anne} and Delphine Cantin and Luc Mouthon and Didier Borderie and Marc Deloger and Delphine Bredel and Severine Mouraud and Damien Drubay and Muriel Andrieu and Lhonneur, {Anne Sophie} and V{\'e}ronique Saada and Annabelle Stoclin and Christophe Willekens and Fanny Pommeret and Frank Griscelli and Ng, {Lai Guan} and Zheng Zhang and Pierre Bost and Ido Amit and Fabrice Barlesi and Aur{\'e}lien Marabelle and Fr{\'e}d{\'e}ric P{\`e}ne and Bertrand Gachot and Fabrice Andr{\'e} and Laurence Zitvogel and Florent Ginhoux and Michaela Fontenay and Eric Solary",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = sep,

day = "17",

doi = "10.1016/j.cell.2020.08.002",

language = "English",

volume = "182",

pages = "1401--1418.e18",

journal = "Cell",

issn = "0092-8674",

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Silvin, A, Chapuis, N, Dunsmore, G, Goubet, AG, Dubuisson, A, Derosa, L, Almire, C, Hénon, C, Kosmider, O, Droin, N, Rameau, P, Catelain, C, Alfaro, A, Dussiau, C, Friedrich, C, Sourdeau, E, Marin, N, Szwebel, TA, Cantin, D, Mouthon, L, Borderie, D, Deloger, M, Bredel, D, Mouraud, S, Drubay, D, Andrieu, M, Lhonneur, AS, Saada, V, Stoclin, A, Willekens, C, Pommeret, F, Griscelli, F, Ng, LG, Zhang, Z, Bost, P, Amit, I, Barlesi, F, Marabelle, A, Pène, F, Gachot, B, André, F, Zitvogel, L, Ginhoux, F, Fontenay, M & Solary, E 2020, 'Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19', Cell, VOL. 182, Numéro 6, p. 1401-1418.e18. https://doi.org/10.1016/j.cell.2020.08.002

TY - JOUR

T1 - Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19

AU - Silvin, Aymeric

AU - Chapuis, Nicolas

AU - Dunsmore, Garett

AU - Goubet, Anne Gaëlle

AU - Dubuisson, Agathe

AU - Derosa, Lisa

AU - Almire, Carole

AU - Hénon, Clémence

AU - Kosmider, Olivier

AU - Droin, Nathalie

AU - Rameau, Philippe

AU - Catelain, Cyril

AU - Alfaro, Alexia

AU - Dussiau, Charles

AU - Friedrich, Chloé

AU - Sourdeau, Elise

AU - Marin, Nathalie

AU - Szwebel, Tali Anne

AU - Cantin, Delphine

AU - Mouthon, Luc

AU - Borderie, Didier

AU - Deloger, Marc

AU - Bredel, Delphine

AU - Mouraud, Severine

AU - Drubay, Damien

AU - Andrieu, Muriel

AU - Lhonneur, Anne Sophie

AU - Saada, Véronique

AU - Stoclin, Annabelle

AU - Willekens, Christophe

AU - Pommeret, Fanny

AU - Griscelli, Frank

AU - Ng, Lai Guan

AU - Zhang, Zheng

AU - Bost, Pierre

AU - Amit, Ido

AU - Barlesi, Fabrice

AU - Marabelle, Aurélien

AU - Pène, Frédéric

AU - Gachot, Bertrand

AU - André, Fabrice

AU - Zitvogel, Laurence

AU - Ginhoux, Florent

AU - Fontenay, Michaela

AU - Solary, Eric

PY - 2020/9/17

Y1 - 2020/9/17

N2 - An analysis of patients with severe COVID-19 reveals immature neutrophil and non-classical monocyte pools, with levels of the protein calprotectin linked to disease severity.

AB - An analysis of patients with severe COVID-19 reveals immature neutrophil and non-classical monocyte pools, with levels of the protein calprotectin linked to disease severity.

KW - COVID-19

KW - S100A8

KW - S100A9

KW - SARS-CoV-2

KW - calprotectin

KW - emergency myelopoiesis

KW - monocyte subsets

KW - neutrophils

KW - type I interferon

UR - http://www.scopus.com/inward/record.url?scp=85089528043&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2020.08.002

DO - 10.1016/j.cell.2020.08.002

M3 - Article

C2 - 32810439

AN - SCOPUS:85089528043

SN - 0092-8674

VL - 182

SP - 1401-1418.e18

JO - Cell

JF - Cell

IS - 6

ER -