Elimination of cDC1 cells by regulatory T cells jeopardizes cancer immunotherapy

Peng Liu, Liwei Zhao, Guido Kroemer, Oliver Kepp

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Résumé

Recent findings revealed that neoantigen-specific cytotoxic type 1 regulatory T (TR1) CD4 T cells can subvert cancer immunotherapy by killing type 1 conventional dendritic cells (cDC1s) that present tumor antigens bound to MHC class II. This underlines the importance of cDC1s for eliciting anticancer immunity but poses a novel clinical challenge.

langue originaleAnglais
Numéro d'article2412874
journalOncoImmunology
Volume13
Numéro de publication1
Les DOIs
étatPublié - 1 janv. 2024
Modification externeOui

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