@article{bd7cb20ac3594decb8f5da9a35e693a9,
title = "Elucidating the gut microbiota composition and the bioactivity of immunostimulatory commensals for the optimization of immune checkpoint inhibitors",
abstract = "Accumulating evidence from preclinical studies and human trials demonstrated the crucial role of the gut microbiota in determining the effectiveness of anticancer therapeutics such as immunogenic chemotherapy or immune checkpoint blockade. In summary, it appears that a diverse intestinal microbiota supports therapeutic anticancer responses, while a dysbiotic microbiota composition that lacks immunostimulatory bacteria or contains overabundant immunosuppressive species causes treatment failure. In this review, we explore preclinical and translational studies highlighting how eubiotic and dysbiotic microbiota composition can affect progression-free survival in cancer patients.",
keywords = "Anticancer therapeutics, Cancer, gut microbiota",
author = "Romain Daill{\`e}re and Bertrand Routy and Goubet, {Anne Ga{\"e}lle} and Alexandria Cogdill and Gladys Ferrere and {Alves-Costa Silva}, Carolina and Aur{\'e}lie Fluckiger and Pierre Ly and Yacine Haddad and Eugenie Pizzato and Cassandra Thelemaque and Marine Fidelle and Marine Mazzenga and Roberti, {Maria Paula} and Cl{\'e}a Melenotte and Peng Liu and Safae Terrisse and Oliver Kepp and Guido Kroemer and Laurence Zitvogel and Lisa Derosa",
note = "Publisher Copyright: {\textcopyright} 2020, {\textcopyright} 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.",
year = "2020",
month = jan,
day = "1",
doi = "10.1080/2162402X.2020.1794423",
language = "English",
volume = "9",
journal = "OncoImmunology",
issn = "2162-4011",
number = "1",
}