Emerging use of senolytics and senomorphics against aging and chronic diseases

Jan Martel, David M. Ojcius, Cheng Yeu Wu, Hsin Hsin Peng, Laurent Voisin, Jean Luc Perfettini, Yun Fei Ko, John D. Young

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    75 Citations (Scopus)

    Résumé

    Senescence is a state of cell cycle arrest that plays an important role in embryogenesis, wound healing and protection against cancer. Senescent cells also accumulate during aging and contribute to the development of age-related disorders and chronic diseases, such as atherosclerosis, type 2 diabetes, osteoarthritis, idiopathic pulmonary fibrosis, and liver disease. Molecules that induce apoptosis of senescent cells, such as dasatinib, quercetin, and fisetin, produce health benefits and extend lifespan in animal models. We describe here the mechanism of action of senolytics and senomorphics, many of which are derived from plants and fungi. We also discuss the possibility of using such compounds to delay aging and treat chronic diseases in humans.

    langue originaleAnglais
    Pages (de - à)2114-2131
    Nombre de pages18
    journalMedicinal Research Reviews
    Volume40
    Numéro de publication6
    Les DOIs
    étatPublié - 1 nov. 2020

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