Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies

Yuting Ma; Heng Yang; Guido Kroemer

doi:10.1080/2162402X.2019.1673635

Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies

Yuting Ma, Heng Yang, Guido Kroemer

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

11 Citations (Scopus)

Résumé

Glucocorticoids mediate potent anti-inflammatory and immunosuppressive effects. A chronic elevation of the endogenous glucocorticoid tonus subsequent to mental stress, as well as continuous treatment with exogenous glucocorticoids, activate an immunosuppressive transcription factor, TSC22D3, in dendritic cells, causing the subversion of cancer therapy-elicited antineoplastic immune responses and subsequent therapeutic failure.

langue originale	Anglais
Numéro d'article	1673635
journal	OncoImmunology
Volume	9
Numéro de publication	1
Les DOIs	https://doi.org/10.1080/2162402X.2019.1673635
état	Publié - 1 janv. 2020

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10.1080/2162402X.2019.1673635

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title = "Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies",

abstract = "Glucocorticoids mediate potent anti-inflammatory and immunosuppressive effects. A chronic elevation of the endogenous glucocorticoid tonus subsequent to mental stress, as well as continuous treatment with exogenous glucocorticoids, activate an immunosuppressive transcription factor, TSC22D3, in dendritic cells, causing the subversion of cancer therapy-elicited antineoplastic immune responses and subsequent therapeutic failure.",

keywords = "Mental stress, TSC22D3, cancer immunotherapy, dendritic cell, glucocorticoid",

author = "Yuting Ma and Heng Yang and Guido Kroemer",

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