TY - JOUR
T1 - Endogenous retroelements in hematological malignancies
T2 - From epigenetic dysregulation to therapeutic targeting
AU - Chour, Mohamed
AU - Porteu, Françoise
AU - Depil, Stéphane
AU - Alcazer, Vincent
N1 - Publisher Copyright:
© 2024 The Author(s). American Journal of Hematology published by Wiley Periodicals LLC.
PY - 2025/1/1
Y1 - 2025/1/1
N2 - Endogenous retroelements (EREs), which comprise half of the human genome, play a pivotal role in genome dynamics. Some EREs retained the ability to encode proteins, although most degenerated or served as a source for novel genes and regulatory elements during evolution. Despite ERE repression mechanisms developed to maintain genome stability, widespread pervasive ERE activation is observed in cancer including hematological malignancies. Challenging the perception of noncoding DNA as “junk,” EREs are underestimated contributors to cancer driver mechanisms as well as antitumoral immunity by providing innate immune ligands and tumor antigens. This review highlights recent progress in understanding ERE co-option events in cancer and focuses on the controversial debate surrounding their causal role in shaping malignant phenotype. We provide insights into the rapidly evolving landscape of ERE research in hematological malignancies and their clinical implications in these cancers.
AB - Endogenous retroelements (EREs), which comprise half of the human genome, play a pivotal role in genome dynamics. Some EREs retained the ability to encode proteins, although most degenerated or served as a source for novel genes and regulatory elements during evolution. Despite ERE repression mechanisms developed to maintain genome stability, widespread pervasive ERE activation is observed in cancer including hematological malignancies. Challenging the perception of noncoding DNA as “junk,” EREs are underestimated contributors to cancer driver mechanisms as well as antitumoral immunity by providing innate immune ligands and tumor antigens. This review highlights recent progress in understanding ERE co-option events in cancer and focuses on the controversial debate surrounding their causal role in shaping malignant phenotype. We provide insights into the rapidly evolving landscape of ERE research in hematological malignancies and their clinical implications in these cancers.
UR - http://www.scopus.com/inward/record.url?scp=85205837231&partnerID=8YFLogxK
U2 - 10.1002/ajh.27501
DO - 10.1002/ajh.27501
M3 - Review article
AN - SCOPUS:85205837231
SN - 0361-8609
VL - 100
SP - 116
EP - 130
JO - American Journal of Hematology
JF - American Journal of Hematology
IS - 1
ER -