Endogenous retroelements in hematological malignancies: From epigenetic dysregulation to therapeutic targeting

Mohamed Chour, Françoise Porteu, Stéphane Depil, Vincent Alcazer

    Résultats de recherche: Contribution à un journalArticle 'review'Revue par des pairs

    Résumé

    Endogenous retroelements (EREs), which comprise half of the human genome, play a pivotal role in genome dynamics. Some EREs retained the ability to encode proteins, although most degenerated or served as a source for novel genes and regulatory elements during evolution. Despite ERE repression mechanisms developed to maintain genome stability, widespread pervasive ERE activation is observed in cancer including hematological malignancies. Challenging the perception of noncoding DNA as “junk,” EREs are underestimated contributors to cancer driver mechanisms as well as antitumoral immunity by providing innate immune ligands and tumor antigens. This review highlights recent progress in understanding ERE co-option events in cancer and focuses on the controversial debate surrounding their causal role in shaping malignant phenotype. We provide insights into the rapidly evolving landscape of ERE research in hematological malignancies and their clinical implications in these cancers.

    langue originaleAnglais
    Pages (de - à)116-130
    Nombre de pages15
    journalAmerican Journal of Hematology
    Volume100
    Numéro de publication1
    Les DOIs
    étatPublié - 1 janv. 2025

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